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Fig. 2 | Genes & Nutrition

Fig. 2

From: Dietary compounds as potent inhibitors of the signal transducers and activators of transcription (STAT) 3 regulatory network

Fig. 2

The JAK/STAT signaling pathway. Ligand binding to the membrane receptor leads to receptor dimerization (1) and activation of associated JAK proteins (2). JAK phosphorylates the receptor (3) to recruit and phosphorylate cytoplasmic STAT factors (4). Phosphorylation of STAT factors leading to their dimerization (5). As a dimer, STAT will be translocated into the nucleus (6) to specifically bind to DNA at the GAS (IFN-gamma-activated site). The STATE dimer activates the transcription of its target genes (7). This figure presents STAT3 and its target genes in the nucleus as an example

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