Table 1 Functional annotation analysis (DAVID) for up- and downregulated genes in the comparison of Control sample to directly frozen human mucosa (DF)
Category | Annotation term | Significance (FDR) | Molecules |
|---|---|---|---|
Upregulated genes | |||
Biological processes (top ten regulated terms) | Apoptosis | 1.53E−07 | 30 |
Death | 1.54E−07 | 31 | |
Cell death | 1.54E−07 | 31 | |
Programmed cell death | 1.86E−07 | 30 | |
Biological regulation | 3.21E−07 | 94 | |
Cell development | 3.71E−06 | 36 | |
Developmental process | 4.20E−06 | 66 | |
Cell differentiation | 6.70E−06 | 45 | |
Cellular developmental process | 6.75E−06 | 45 | |
Negative regulation of biological process | 1.02E−05 | 34 | |
Cellular components | Intracellular part | 3.29E−02 | 130 |
Molecular functions | Protein binding | 1.27E−07 | 113 |
|  | Binding | 1.18E−02 | 153 |
KEGG pathway | Complement and coagulation cascades | 4.83E−03 | 7 |
Downregulated genes | |||
Cellular components | Organelle membrane | 2.36E−04 | 14 |
Mitochondrial inner membrane | 9.46E−03 | 6 | |
Organelle inner membrane | 1.28E−02 | 6 | |
Cytoplasmic part | 2.34E−02 | 19 | |
Mitochondrial part | 2.48E−02 | 7 | |
Mitochondrial membrane | 2.84E−02 | 6 | |
Mitochondrion | 3.13E−02 | 9 | |
Organelle envelope | 3.45E−02 | 7 | |
Mitochondrial envelope | 3.50E−02 | 6 | |
Envelope | 3.52E−02 | 7 | |
Integral to organelle membrane | 3.97E−02 | 4 | |
Membrane | 4.01E−02 | 28 | |