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Table 2 Differentially expressed genes in Cluster 6

From: Lactobacillus paracasei and Lactobacillus plantarum strains downregulate proinflammatory genes in an ex vivo system of cultured human colonic mucosa

Symbol

Gene

Fold changea

Inflamed

iLP

iLP(A−)

iBL23

IL17A

Interleukin 17A

14.3

6.9

5.6

5.9

CXCL11

Chemokine (C-X-C motif) ligand 11

10.9

4.2

6.6

3.1

IFNG

Interferon, gamma

10.5

5.9

4.8

4.4

CXCL9

Chemokine (C-X-C motif) ligand 9

9.9

3.0

3.5

2.4

IL2

Interleukin 2

9.5

2.2

2.2

2.8

XCL1

Chemokine (C motif) ligand 1

7.7

4.3

3.3

4.1

GZMB

Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

6.5

2.3

3.2

2.6

TNFRSF9

Tumor necrosis factor receptor superfamily, member 9

4.5

1.9

2.3

1.6

INDO

Indoleamine-pyrrole 2,3 dioxygenase

4.5

1.8

1.3

1.6

XIRP1

Xin actin-binding repeat containing 1

4.4

2.8

2.7

2.2

RNF19B

Ring finger protein 19B

4.2

1.3

2.2

1.6

ZBED2

Zinc finger, BED-type containing 2

3.7

2.4

1.7

1.9

GBP1

Guanylate-binding protein 1, interferon-inducible, 67 kDa

3.5

2.0

1.6

2.0

IRF1

Interferon regulatory factor 1

3.2

2.5

2.9

2.4

CRTAM

Cytotoxic and regulatory T cell molecule

3.2

2.3

1.7

2.1

CD226

CD226 molecule

3.0

1.4

1.6

1.5

ENPP3

Ectonucleotide pyrophosphatase/phosphodiesterase 3

3.0

1.4

1.9

1.6

GBP4

Guanylate-binding protein 4

2.9

1.6

1.6

1.3

UBD

Ubiquitin D

2.9

2.2

2.4

1.9

MYC

v-myc myelocytomatosis viral oncogene homolog (avian)

2.9

1.8

1.3

2.2

IL2RA

Interleukin 2 receptor, alpha

2.7

2.1

1.7

2.0

TNFRSF4

Tumor necrosis factor receptor superfamily, member 4

2.7

1.8

1.5

1.6

ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

2.7

1.6

−1.1

1.6

EGR2

Early growth response 2

2.6

2.1

2.3

2.0

GBP2

Guanylate-binding protein 2, interferon-inducible

2.1

1.9

2.0

1.8

IRF1

Interferon regulatory factor 1

2.4

2.3

2.6

2.3

GJA4

Gap junction protein, alpha 4, 37 kDa

2.3

2.0

2.7

2.1

DUOX1

Dual oxidase 1

2.1

1.3

1.4

1.8

STK19

Serine/threonine kinase 19

2.1

1.3

1.2

1.4

CPN1

Carboxypeptidase N, polypeptide 1

2

1.5

1.3

1.7

CTSS

Cathepsin S

2.0

1.3

1.3

1.1

CYB561

Cytochrome b-561

1.9

1.3

1.9

1.4

PPP1R11

Protein phosphatase 1, regulatory (inhibitor) subunit 11

1.8

1.0

1.2

1.1

  1. aFold changes are expressed relative to Control
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Genes & Nutrition

ISSN: 1865-3499

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