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Table 3 Functional annotations analysis corresponding to up- and downregulated genes in Inflamed compared to Control and to downregulated genes in iBL23, iLP and iLP(A−) compared to Inflamed sample (The analysis is based on the default parameters in D.A.V.I.D. and uses FDR correction for multiple testing)

From: Lactobacillus paracasei and Lactobacillus plantarum strains downregulate proinflammatory genes in an ex vivo system of cultured human colonic mucosa

 

Inflamed versus CTRL

iLP versus Inflamed

iLP(A−) versus Inflamed

iBL23 versus Inflamed

Category

↑ Regulated genes

↓ Regulated genes

↓ Regulated genes

↓ Regulated genes

↓ Regulated genes

Biological Processes

Immune response

Response to wounding

Immune response

Immune response

Immune response

 

Immune system process

Wound healing

Taxis

Immune system process

Immune system process

 

Positive regulation of immune system process

Regulation of localization

Chemotaxis

Response to external stimulus

Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

 

Regulation of lymphocyte proliferation

Regulation of transport

Response to external stimulus

Response to wounding

Regulation of adaptive immune response

 

Regulation of leukocyte proliferation

Response to external stimulus

Immune system process

Response to stimulus

Response to external stimulus

Cellular components

ns

ns

Extracellular space

Extracellular space

Extracellular space

   

Extracellular region part

Extracellular region part

Extracellular region part

    

Extracellular region

Extracellular region

Molecular functions

Cytokine activity

Heparin binding

Cytokine activity

Cytokine activity

Cytokine activity

  

Glycosaminoglycan binding

Chemokine activity

Receptor binding

Receptor binding

  

Pattern binding

Chemokine receptor binding

Chemokine activity

Chemokine activity

  

Polysaccharide binding

G-protein-coupled receptor binding

Chemokine receptor binding

G-protein-coupled receptor binding

   

Receptor binding

G-protein-coupled receptor binding

Chemokine receptor binding

KEGG pathways

Cytokine–cytokine receptor interaction

ns

Cytokine–cytokine receptor interaction

Cytokine–cytokine receptor interaction

Cytokine–cytokine receptor interaction

    

Jak-STAT signaling pathway

Jak-STAT signaling pathway

  1. KEGG Kyoto encyclopedia of genes and genomes; ns none significant