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Table 1 Demographic characteristics and descriptive statistics of genotyped study participants

From: PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer

 

Colon

p

Rectum

p

Control

Case

Control

Case

n = 1,900

n = 1,543

n = 912

n = 712

n (%)

n (%)

n (%)

n (%)

Age

 30–39

40 (2.1)

23 (1.5)

 

17 (1.9)

19 (2.7)

 

 40–49

127 (6.7)

100 (6.5)

 

100 (11.0)

85 (11.9)

 

 50–59

315 (16.6)

289 (18.7)

 

230 (25.2)

188 (26.4)

 

 60–69

651 (34.2)

535 (34.7)

 

316 (34.7)

236 (33.2)

 

 70–79

767 (40.4)

596 (38.6)

 

249 (27.3)

184 (25.8)

 

 Mean

65.0

64.88

NA

62.2

61.46

NA

Center

      

 Utah

347 (18.3)

250 (16.2)

NA

343 (37.6)

248 (34.8)

NA

 KPMCP

760 (40.0)

720 (46.7)

 

569 (62.4)

464 (65.2)

 

 Minnesota

793 (41.7)

573 (37.1)

 

NA

NA

 

Race/ethnicity

 NHW

1,773 (93.3)

1,417 (91.8)

NA

782 (85.8)

589 (82.7)

NA

 Hispanic

72 (3.8)

56 (3.6)

 

63 (6.9)

57 (8.0)

 

 Black

55 (2.9)

70 (4.5)

 

40 (4.3)

28 (3.9)

 

 Asian

NA

NA

 

27 (3.0)

38 (5.3)

 

Sex

 Male

1,010 (53.2)

862 (55.9)

NA

512 (56.1)

427 (60.0)

NA

 Female

890 (46.8)

681 (44.1)

 

400 (43.9)

285 (40.0)

 

Aspirin/NSAID use

 No recent use

1,099 (58.3)

1,042 (68.3)

<0.0001

497 (55.0)

449 (63.0)

0.0005

 Recent use

787 (41.7)

485 (31.8)

 

407 (45.0)

257 (36.4)

 

Family history of CRC, n (%)

 Yes

180 (9.5)

251 (16.3)

<0.0001

76 (8.3)

83 (11.7)

0.03

 No

1,720 (90.5)

1,292 (83.7)

 

836 (91.7)

629 (88.3)

 

Total energy intake (kcal)

2,320

2,451

0.0005

2,595

2,752

0.02

Long term PAI

 Mean

7.0

6.5

<0.0001

7.6

7.0

0.0004

BMI

 –

26.7

27.8

<0.0001

27.4

27.7

0.18

Fat/fatty acid intake

(g)

(g)

 

(g)

(g)

 

 Total fat

84.1

91.5

<0.0001

103.2

111.2

0.02

 SFA

31.3

34.0

0.0002

34.8

37.6

0.02

 MUFA

30.3

33.1

<0.0001

37.0

40.1

0.01

 PUFA

15.8

17.0

0.0001

23.7

25.1

0.07

 LA

13.9

15.0

0.0001

21.1

22.4

0.09

 AA

0.14

0.2

<0.0001

0.12

0.14

0.0002

 EPA

0.02

0.02

0.60

0.02

0.02

0.22

 DHA

0.08

0.08

0.25

0.08

0.09

0.07

 n-3 PUFA

1.8

1.9

0.0003

2.4

2.6

0.01

Dietary cholesterol (mg)

275

308

<0.0001

305

351

<0.0001

  1. BMI body mass index (weight/height2 for men, weight/height1.5 for women), PAI physical activity index, SFA saturated fatty acids = 4:0, 6:0, 8:0, 10:0, 12:0, 14:0, 16:0, 17:0, 18:0, 20:0, 22:0, MUFA monounsaturated fatty acids = 14:1, 16:1, 18:1, 20:1, 22:1, PUFA polyunsaturated fatty acids = 18:2, 18:3, 20:4, 20:5, 22:6, n-3 PUFA = 18:3, 20:5, 22:6, NHW non-Hispanic Whites, NSAIDs nonsteroidal anti-inflammatory drugs, CRC colorectal cancer
  2. Bold values are statistically significant