Genes & Nutrition

Table 3 Associations of SNPs in PTGS1 and ALOX12 2 and risk of rectal cancer stratified by fat and fatty acid intake

From: PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer

Gene	SNP	Fat/fatty acid	Genotype	Rectum fat/fatty acid intake
				Low	Intermediate	High
				OR^a (95 % CI)	OR^a (95 % CI)	OR^a (95 % CI)
PTGS1	rs10306122 (2,125 T > C)	Total fat	AA	1.00	0.94 (0.69, 1.27)	1.12 (0.77, 1.62)
			AG/GG	1.75 (1.02, 2.99)	1.22 (0.70, 2.11)	0.76 (0.46, 1.28)
			p-interaction^a		0.005
			Adjusted p ^b		0.08
		MUFA	AA	1.00	0.97 (0.71, 1.32)	1.15 (0.80, 1.67)
			AG/GG	1.84 (1.07, 3.18)	1.03 (0.60, 1.77)	0.87 (0.51, 1.46)
			p-interaction^a		0.01
			Adjusted p ^b		0.16
ALOX12	rs11571339 (7,135 A > G)	n-3	AA	1.00	1.14 (0.83, 1.57)	0.91 (0.64, 1.31)
			AG/GG	0.47 (0.23, 0.93)	1.29 (0.77, 2.19)	1.05 (0.63, 1.73)
			p-interaction^a		0.046
			Adjusted p ^b		0.79
		18:02	AA	1.00	0.92 (0.66, 1.28)	0.89 (0.63, 1.27)
			AG/GG	0.45 (0.21, 0.95)	0.90 (0.53, 1.55)	1.07 (0.66, 1.73)
			p-interaction^a		0.03
			Adjusted p ^b		0.50
		PUFA	AA	1.00	0.95 (0.69, 1.32)	0.87 (0.61, 1.23)
			AG/GG	0.48 (0.23, 1.00)	0.87 (0.50, 1.49)	1.08 (0.67, 1.75)
			p-interaction^a		0.02
			Adjusted p ^b		0.41

Only SNPs with statistically significant interactions are shown
Bold values are statistically significant
^aAdjusted for age, study center, ethnicity, sex, family history of disease, recent NSAID use (where appropriate), BMI, physical activity, dietary cholesterol, and caloric intake
^bBonferroni adjusted

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ISSN: 1865-3499

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