Correlation of G/A -22018 single-nucleotide polymorphism with lactase activity and its usefulness in improving the diagnosis of adult-type hypolactasia among North Indian children

Table 2 Self-reported gastrointestinal symptoms in relation to milk consumption for various lactase genotypes

Gastrointestinal symptoms*	Genotype		Total	P value
	C/C -13910	C/T + T/T -13910
	G/G -22018	G/A + A/A -22018
	n/N (%)	n/N (%)	n/N (%)
≤250 ml/day milk intake^†
Flatulence	15/54 (28)	9/36 (25)	24/90 (27)	0.77^‡
Bloating	14/54 (26)	7/36 (19)	21/90 (23)	0.47^‡
Diarrhea	10/54 (19)	6/36 (17)	16/90 (18)	0.82^‡
Borborygmi	13/54 (24)	9/36 (25)	22/90 (24)	0.92^‡
Constipation	7/54 (13)	2/36 (5.6)	9/90 (10)	0.23^‡
>250 ml/day milk intake
Flatulence	42/54 (79)^§	13/36 (36)	55/90 (61)	<0.001^‡
Bloating	19/54 (35)	9/36 (25)	28/90 (31)	0.30^‡
Diarrhea	13/54 (24)	8/36 (22)	21/90 (23)	0.83^‡
Borborygmi	19/54 (35)	11/36 (31)	30/90	0.64^‡
Constipation	7/54 (13)	2/36 (5.6)	(33) 9/90 (10)	0.23^‡

* Self-reported gastrointestinal symptoms
^†Approximately one cup or less of milk per day
^‡ P value based on χ ² test
^§Significantly different from number of flatulence cases in ≤ 250 ml/day milk intake group for C/C -13910 and G/G -22018 lactase genotypes (P < 0.001)

ISSN: 1865-3499