Effect of rosemary polyphenols on human colon cancer cells: transcriptomic profiling and functional enrichment analysis

Table 2 Over-represented down-regulated gene sets microarray transcriptomics data obtained from treatment of colon cancer cells with rom4 extract

Cell line	Name	Size	NES^a	NOM p val^b	FDR q val^c
HT29	Sister chromatid segregation	16	−1.97	0.000	0.044
	Mitotic sister chromatid segregation	15	−2.00	0.000	0.064
	Cell cycle process	176	−1.89	0.000	0.075
	Chromosome segregation	30	−1.84	0.002	0.079
	Cytokinesis	18	−1.85	0.000	0.088
	Mitotic cell cycle	140	−1.78	0.000	0.090
	Cell cycle phase	158	−1.79	0.000	0.092
	Mitosis	75	−1.75	0.000	0.094
	M phase	103	−1.74	0.003	0.096
	M phase of mitotic cell cycle	77	−1.80	0.000	0.097
	Chromosome organization and biogenesis	110	−1.76	0.000	0.098
	DNA repair	107	−1.72	0.000	0.109
	Cell cycle	286	−1.70	0.000	0.120
	Regulation of membrane potential	15	−1.66	0.027	0.138
	mRNA processing	66	−1.67	0.005	0.140
	RNA splicing	76	−1.65	0.000	0.142
	Positive regulation of secretion	17	−1.63	0.014	0.157
	Double strand break repair	20	−1.60	0.022	0.165
	Cell cycle checkpoint	43	−1.61	0.017	0.167
	DNA recombination	41	−1.60	0.020	0.169
	Microtubule cytoskeleton organization and biogenesis	33	−1.58	0.033	0.185
	Response to DNA damage stimulus	138	−1.56	0.006	0.207
	Cell division	20	−1.55	0.043	0.207
SW480	Sister chromatid segregation	16	−1.87	0.003	0.081
	Cell division	20	−1.91	0.005	0.108
	Mitotic sister chromatid segregation	15	−1.81	0.000	0.109
	Cytokinesis	18	−1.77	0.005	0.121
	Chromosome segregation	30	−1.66	0.003	0.199
	Extracellular structure organization and biogenesis	29	−1.62	0.017	0.202
	M phase of mitotic cell cycle	77	−1.62	0.000	0.219
	Mitosis	75	−1.62	0.005	0.244

ISSN: 1865-3499