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Table 1 Hepatic proteome of the male offspring at 6 months of age

From: A methyl-deficient diet fed to rats during the pre- and peri-conception periods of development modifies the hepatic proteome in the adult offspring

Spot ID no

Protein identity

NCBI

CON

MD

P

Mean

SEM

Mean

SEM

Energy metabolism

7301

Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12).

P04797

62.3

6.5

26.1

4.8

0.000

6605

UDP-glucose dehydrogenase

O70199

32.3

3.3

17.8

2.7

0.002

7601

UDP-glucose 6-dehydrogenase

O70199

8.4

2.0

3.1

1.0

0.015

5714

PEPCK cytosolic

P07379

23.2

8.9

3.9

1.1

0.026

8401

Phosphoglycerate kinase

P16617

262.3

16.1

163.5

46.3

0.035

5702

Phosphoglucomutase

Q499Q4

43.2

14.1

13.8

4.1

0.036

8315

Fructose-bisphosphate aldolase

P00884

684.0

107.9

383.1

113.2

0.043

6507

UDP-glucose pyrophosphorylase 2

Q4V8I9

94.5

6.5

68.8

8.0

0.012

4305

Pyridoxal kinase

O35331

8.3

1.0

13.5

2.0

0.019

8602

Methyl-malonate semi-aldehyde dehydrogenase

Q02253

30.2

7.2

59.9

9.7

0.013

7404

Fumarate hydratase precursor, mitochondrial

Q5M964

73.7

10.5

47.4

5.5

0.023

5408

Fumarylacetoacetase

P25093

27.2

6.6

13.6

2.1

0.040

6001

Nucleoside diphosphate kinase

P19804

35.8

2.8

28.4

2.5

0.040

2404

5′-bisphosphate nucleotidase

Q9Z1N4

9.2

1.8

15.2

2.6

0.044

6708

Glucokinase regulatory protein

Q07071

14.7

5.2

2.4

0.4

0.016

Antioxidant defence

7702

Catalase

P04762

67.1

8.4

128.2

19.8

0.005

7602

Catalase

P04762

418.1

59.1

270.3

19.1

0.016

6703

Catalase

P04762

115.0

9.4

91.8

6.6

0.035

7103

Glutathione transferase cytosolic

P04906

11.2

2.5

24.2

4.2

0.008

7104

Glutathione-S transferase

P08009

18.8

4.9

5.7

2.0

0.013

7004

Thioredoxin reductase (peroxiredoxin-4)

Q9Z0V5

55.1

5.3

33.9

7.5

0.019

4504

Selenium binding protein

Q8VIF7

149.7

8.7

200.2

25.3

0.047

4106

Peroxiredoxin-6 (EC 1.11.1.15)

O35244

19.0

2.7

27.9

2.8

0.019

Amino acid and peptide metabolism

6602

Cysteine sulphinic acid decarboxylase

Q64611

15.4

2.6

8.7

2.4

0.048

2206

3-hydroxyanthranilate 3,4-dioxygenase

P46953

9.0

2.1

18.2

3.0

0.013

7901

Carbamoyl-phosphate synthetase

P07756

8.1

1.3

30.3

9.4

0.018

5902

Carbamoyl-phosphate synthetase

P07756

7.5

1.8

15.0

2.9

0.023

908

Carbamoyl-phosphate synthetase

P07756

8.0

3.9

0.5

0.3

0.044

2608

Dipeptidase 3 (rat)

Q5U2X4

6.4

0.7

8.6

0.4

0.006

5302

Arginase

P07824

69.5

9.0

41.6

9.6

0.028

6504

Homogentisate 1,2-dioxygenase

Q6AYR0

12.4

2.6

21.7

3.7

0.032

Miscellaneous

1007

BAB24222 (Mus musculus)

UNK

4.8

0.7

7.8

1.2

0.020

1203

Annexin IV (36-kDa zymogen granule membrane)

Q5U362

15.1

2.2

20.2

1.3

0.038

2706

Choline dehydrogenase

Q6UPE0

5.6

0.5

8.6

1.1

0.016

3005

Bendless protein (Ubiquitin-conjugating enezyme E2)

Q9EQX9

4.2

0.4

5.9

0.8

0.047

4810

Formyltetrahydrofolate dehydrogenase (EC 1.5.1.6)

P28037

3.8

0.6

6.2

1.0

0.035

5308

3-alpha-hydroxysteroid dehydrogenase

P23457

69.6

4.0

58.0

4.8

0.048

6209

Thyroid hormone sulphotransferase

P52847

39.8

4.9

27.1

2.5

0.018

6802

Serotransferrin, Liver regeneration related protein LLRG03

P12346

51.6

7.1

34.8

4.2

0.034

7302

Dynamin-1-like protein

O35303

23.3

3.7

10.7

2.0

0.004

8508

Betaine–homocysteine S-methyltransferase 1

O09171

47.7

21.5

132.8

37.2

0.038

  1. Offspring were from dams fed complete (CON) or methyl-deficient (MD) diets. Data are mean pixel density ± SEM, n = 8 in each group. Data compared by Student’s t test