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Table 4 Odds ratios (OR) and 95 %CI for association of dietary folate concentrations with prostate cancera

From: Complex interaction between serum folate levels and genetic polymorphisms in folate pathway genes: biomarkers of prostate cancer aggressiveness

 

Tertiles of dietary folate

p trend

1

OR

2

OR

3

OR (95 % CI)

Folate intake (μg/d)

172–634

635–926

927–1121

 

Total prostate cancera

 Cases/controls

69/75

79/76

61/76

 

 Multivariableb

1.00 (ref.)

2.24 (0.95–5.55)

2.49 (1.16–5.19)

0.006

 Low-grade cancerc

    

 Cases/controls

34/75

38/80

29/79

 

 Multivariableb

1.00 (ref.)

3.27 (0.99–10.86)

2.58 (1.05–6.34)

0.004

High-grade cancerd

 Cases/controls

33/75

40/80

28/79

 

 Multivariableb

1.00 (ref)

1.38 (0.49–3.62)

1.92 (1.01–5.47)

0.019

  1. a7 cases—Gleason scores unknown
  2. bModels adjusted for age and BMI and total energy intake as continuous, education (primary or less, secondary or higher), family history of prostate cancer (no/yes), vitamin use (no/yes), alcohol intake (non-drinker, < 6.4, > 6.4 g/day), and smoking (non-smoker, ex-smoker, current smoker)
  3. cLow-grade cancer indicates Gleason score of <7
  4. dHigh-grade cancer indicates Gleason score of >7