Time-dependent network analysis reveals molecular targets underlying the development of diet-induced obesity and non-alcoholic steatohepatitis

Table 2 Top 5 core diet-induced obesity networks generated with IPA, based on high-fat diet responsive genes identified in long-term high-fat diet-fed C57BL/6 J mice

ID^a	1	2	3	4	5
Associated network functions^b	Cell-to-cell signaling and interaction, hematological system development and function, cellular movement	Lipid metabolism, small molecule biochemistry, endocrine system disorders	Hepatic system disease, lipid metabolism, molecular transport	Inflammatory response, cellular movement, immunological disease	Hepatic system disease, lipid metabolism, molecular transport
Representative molecules in network^c	Acacb, Apom, Ccnd1, Cd14, Cdkn1a, Tlr2	Acox1, Cidea/C, Lpl, S100a11	Krt8, Pdzk1	Cd274, Lgmn, Lyz, Saa2	Cyp7a1, Fdps, Socs2
Score^d	34	18	15	14	13
Focus molecules^e	28	16	17	16	15

Network^a numbers assigned in the order of the significant score, and associated network functions^b is the three most significant functions for each network
Representative molecules in network^c mean the genes showing a time-dependent steady expression pattern in each network
^dScore is based on a p value calculation, which calculate the likelihood that the network eligible molecules that are part of a network found therein by random chance alone and the greater the number of network eligible molecules in a network, the higher the score (lower the p value) will be
^eFocus molecules indicates the number of network eligible molecules, the genes that are eligible for network generation, per network Top Functions in the most significant functions for each network

ISSN: 1865-3499