Association between the rs6950982 polymorphism near the SERPINE1 gene and blood pressure and lipid parameters in a high-cardiovascular-risk population: interaction with Mediterranean diet

Table 1 Anthropometric, clinical, biochemical, lifestyle and genetic characteristics of participants

Variables	Total (n = 945)	Male (n = 340)	Female (n = 605)	P*
Age (years)	67.3 ± 6.2	66.8 ± 5.9	67.60 ± 6.6	0.053
BMI (kg/m²)	30.9 ± 5.1	29.4 ± 4	31.7 ± 5.2	<0.001
TC (mg/dl)	208 ± 40	200 ± 38	212 ± 40	<0.001
HDL-C (mg/dl)	53 ± 14	49 ± 12	56 ± 14	<0.001
LDL-C (mg/dl)	129 ± 36	124 ± 37	131 ± 36	0.004
TG (mg/dl)	131 ± 81	137 ± 74	127 ± 84	0.025
Fasting glucose (mg/dl)	123 ± 40	129 ± 42	119 ± 39	0.001
SBP (mmHg)	147 ± 22	147 ± 21	146 ± 23	0.655
DBP (mmHg)	82 ± 11	82 ± 11	81 ± 11	0.498
MD adherence score	8.48 ± 2.0	8.6 ± 2.0	8.4 ± 2.0	0.097
Diabetes (%)	48.5	56	44.3	0.001
Hypertension (%)	79.7	71.4	84.4	<0.001
Anti-hypertensive agents (%)	66.7	57.3	71.9	<0.001
Current smokers (%)	11.9	26.7	3.6	<0.001
SERPINE1 A > G (rs6950982) polymorphism				0.09
AA (n = 566)	60.5	61.4	60.9
AG (n = 320)	34.2	31.3	35.0
GG (n = 49)	5.2	7.2	4.1

Values are presented as mean ± standard deviation for continuous variables or % for categorical variables
BMI Body mass index, TC total cholesterol, TG triglyceride, SBP systolic blood pressure, DBP diastolic blood pressure, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, MD Mediterranean diet
* P value for comparisons between males and females

ISSN: 1865-3499