Association between the rs6950982 polymorphism near the SERPINE1 gene and blood pressure and lipid parameters in a high-cardiovascular-risk population: interaction with Mediterranean diet

Table 2 Clinical parameters in the whole population (men and women) depending on the rs6950982 SERPINE1 polymorphism

	AA (n = 566)	AG (n = 320)	GG (n = 49)	P*	P**	P ^{^}
Age (years)	67.2 ± 6.2	67.6 ± 6.1	68.2 ± 6.8	0.724	0.690	0.256
Score to MD adherence	8.5 ± 2.0	8.4 ± 2.0	8.5 ± 1.8	0.989	0.526	0.968
SBP (mmHg)	146.5 ± 22.0	146.3 ± 23.0	151.1 ± 19.5	0.327	0.956	0.208
DBP (mmHg)	81.2 ± 10.4	82.1 ± 11.7	82.0 ± 11.2	0.129	0.365	0.583
TC (mg/dl)	208 ± 41	210 ± 37	218 ± 48	0.039	0.016	0.011
HDL-C (mg/dl)	53 ± 14	54 ± 13.3	52 ± 13	0.367	0.915	0.911
LDL-C (mg/dl)	127 ± 36	131 ± 34	136 ± 44	0.065	0.032	0.031
TG (mg/dl)	131 ± 69	128 ± 67	154 ± 111	0.013	0.040	0.029
Fasting glucose (mg/dl)	123 ± 41	123 ± 42	122 ± 40	0.847	0.936	0.721
Current smokers (%)	12.2	10.2	16.1	0.778	0.891	0.777
Hypertension (%)	77.8	82.7	83.6	0.139	0.365	0.342

Values are presented as mean ± standard deviation for continuous variables or % for categorical variables
MD Mediterranean diet, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, TG triglyceride, FG fasting glucose, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol
* P for linear trend (additive effects were estimated including: 0, 1 or 2 variant alleles). Unadjusted analysis
** P value for the additive model adjusted by sex, age and anti-hypertensive agents or lipid-lowering agents
^{^} P value for recessive effects adjusted by sex, age and anti-hypertensive agents or lipid-lowering agents
P values in bold indicate statistically significant associations (P < 0.05)

ISSN: 1865-3499