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Table 3 Clinical parameters in men depending on the rs6950982 SERPINE1 polymorphism

From: Association between the rs6950982 polymorphism near the SERPINE1 gene and blood pressure and lipid parameters in a high-cardiovascular-risk population: interaction with Mediterranean diet

 

AA (n = 204)

AG (n = 104)

GG (n = 24)

P*

P**

P ^

MD adherence score

8.7 ± 2.1

8.6 ± 2.0

8.6 ± 1.8

0.860

0.921

0.784

SBP (mmHg)

146.3 ± 20.5

147.3 ± 23.3

155.8 ± 18.5

0.072

0.237

0.036

DBP (mmHg)

81.5 ± 10.9

82.1 ± 11.4

85.7 ± 10.5

0.030

0.130

0.096

TC (mg/dl)

197 ± 36

201 ± 38

225 ± 44

0.002

0.005

0.001

LDL-C (mg/dl)

122 ± 34

126 ± 35

147 ± 45

0.009

0.008

0.002

TG (mg/dl)

136 ± 73

137 ± 69

152 ± 76

0.090

0.377

0.232

  1. Values are presented as mean ± standard deviation for continuous variables
  2. MD Mediterranean diet, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglyceride
  3. P for linear trend (additive effects were estimated including: 0, 1 or 2 variant alleles). Unadjusted analysis
  4. ** P value for the additive model adjusted for age and anti-hypertensive agents or lipid-lowering agents
  5. ^ P value for recessive model adjusted for age and anti-hypertensive agents or lipid-lowering agents
  6. P values in bold indicate statistically significant associations (P < 0.05)