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Table 2 Replication sample of responders and non-responders pre- and post-n-3 PUFA supplementation

From: Differences in metabolomic and transcriptomic profiles between responders and non-responders to an n-3 polyunsaturated fatty acids (PUFAs) supplementation

 

Responders (n = 60)

Non-responders (n = 60)

P value between resp. and non-resp.

Pre-n-3 PUFAs

Post-n-3 PUFAs

P value

Pre-n-3 PUFAs

Post-n-3 PUFAs

P value

Pre-n-3 PUFAs

Delta (post- and pre-n-3 PUFAs)

Gender

26 men (43 %) and 34 women (57 %)

30 men (50 %) and 30 women (50 %)

NS

 

Age (years)

32.02 ± 1.11 years

31.1 ± 1.16 years

NS

 

BMI (kg/m²)

29.3 ± 0.5

29.3 ± 0.5

NS

27.8 ± 0.5

28.0 ± 0.5

0.0007

NS

NS

Triacylglycerolsa (mmol/L)

1.61 ± 0.09

0.99 ± 0.06

<0.0001

1.03 ± 0.06

1.20 ± 0.07

<0.0001

<0.0001

<0.0001

Cholesterol (mmol/L)

        

 Total

4.94 ± 0.12

4.83 ± 0.13

NS

4.77 ± 0.13

4.87 ± 0.14

NS

NS

0.0264

 LDL

2.87 ± 0.11

2.94 ± 0.12

NS

2.79 ± 0.12

2.84 ± 0.13

NS

NS

NS

 HDLa

1.33 ± 0.05

1.44 ± 0.05

<0.0001

1.50 ± 0.05

1.48 ± 0.05

NS

0.0142

0.0001

Ratio TC/HDL-C

3.90 ± 0.13

3.59 ± 0.14

<0.0001

3.33 ± 0.12

3.48 ± 0.14

0.0054

0.0018

<0.0001

Apo-B 100 (g/L)

0.89 ± 0.03

0.91 ± 0.03

NS

0.83 ± 0.03

0.88 ± 0.03

0.0015

NS

NS

Ratio LDL/Apo-B

3.28 ± 0.06

3.20 ± 0.05

NS

3.36 ± 0.06

3.20 ± 0.07

0.0098

NS

NS

Glucose (mmol/L)a

5.15 ± 0.06

5.17 ± 0.06

NS

4.94 ± 0.05

5.04 ± 0.07

NS

0.0155

NS

Insulin (pmol/L)a,*

84.93 ± 3.47

80.91 ± 3.35

NS

75.31 ± 3.31

82.70 ± 3.90

0.0456

0.0226

NS

CRPa(mg/L)

2.78 ± 0.47

2.69 ± 0.40

NS

2.87 ± 0.68

3.06 ± 0.83

NS

NS

NS

  1. Data are shown as mean ± SEM
  2. TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol
  3. * Subjects excluded for responders (n = 5 for pre-n-3 PUFAs and n = 3 for post-n-3 PUFAs) and non-responders (n = 2 for pre-n-3 PUFAs and n = 4 for post-n-3 PUFAs)
  4. a P value derived from transformed data