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Table 5 Changes in the expression of genes in PBMCs involved in sphingolipid metabolism after n-3 PUFA supplementation in responders and non-responders (P = 0.27 and P = 0.04, respectively)

From: Differences in metabolomic and transcriptomic profiles between responders and non-responders to an n-3 polyunsaturated fatty acids (PUFAs) supplementation

Gene symbol

Gene name

Responders (n = 6)

Non-responders (n = 6)

ACER2

Alkaline ceramidase 2

 

1.378

ARSK

Arylsulfatase family, member K

−1.209

 

ASAH1

N-Acylsphingosine amidohydrolase (acid ceramidase) 1

 

−1.281

ASAH2C

N-Acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2C

−1.361

−1.226

ENPP7

Ectonucleotide pyrophosphatase/phosphodiesterase 7

1.212

 

FUT7

Fucosyltransferase 7 (alpha (1,3) fucosyltransferase)

 

−1.608

GBA3

Glucosidase, beta, acid 3 (cytosolic)

 

−1.419

KDSR

3-Ketodihydrosphingosine reductase

1.244

1.223

PIGO

Phosphatidylinositol glycan anchor biosynthesis, class O

1.279

 

PPAP2A

Phosphatidic acid phosphatase type 2A

1.336

1.207

PPAP2B

Phosphatidic acid phosphatase type 2B

 

1.283

PPAP2C

Phosphatidic acid phosphatase type 2C

1.251

−1.462

PPAPDC1A

Phosphatidic acid phosphatase type 2 domain containing 1A

−1.276

 

PTPRJ

Protein tyrosine phosphatase, receptor type, J

 

−1.241

SGMS1

Sphingomyelin synthase 1

 

1.244

SGMS2

Sphingomyelin synthase 2

 

−1.233

SGPP1

Sphingosine-1-phosphate phosphatase 1

 

−1.271

SPHK1

Sphingosine kinase 1

1.247

 

UGT8

UDP glycosyltransferase 8

 

−1.315