Table 2 PBMC mRNA expression levels in normal weight, at-risk obese (ARO) and metabolically healthy but obese (MHO) subjects (median with 25–75 percentiles)

 ADRP^d

1.08 (0.9–1.2)

1.05 (0.9–1.2)

1.14 (0.9–1.3)

–

–

–

 CD36^d

0.85 (0.8–1.3)

0.96 (0.8–1.2)

1.14 (0.8–1.4)

–

–

–

 CPT1A^d

1.18 (0.9–1.3)

0.86 (0.8–1.3)

1.14 (0.7–1.6)

–

–

–

 FABP4^d

0.64 (0.4–1.5)

0.46 (0.3–0.7)

0.69 (0.6–0.9)

–

–

–

 LIPE

0.38 (0.3–0.5)

0.28 (0.2–0.4)

0.46 (0.4–0.5)

0.035

–

0.003

 LPL^d

0.59 (0.3–1.5)

0.76 (0.4–1.6)

0.56 (0.2–1.9)

–

–

–

 LXR

0.20 (0.2–0.3)

0.22 (0.2–0.3)

0.22 (0.2–0.3)

–

–

–

 NAMPT

3.33 (3.2–4.3)

3.23 (2.8–3.5)

2.87 (2.5–3.5)

–

–

–

 PLA2G4A

0.33 (0.2–0.3)

0.25 (0.2–0.3)

0.29 (0.2–0.4)

–

–

–

 PLA2G7

0.55 (0.4–1.0)

0.40 (0.2–0.6)

0.75 (0.3–1.0)

–

–

–

 PLTP

0.14 (0.1–0.2)

0.11 (0.1–0.2)

0.11 (0.1–0.2)

–

–

–

 PPARδ

1.39 (1.2–1.8)

1.08 (1.0–1.3)

1.40 (1.4–1.6)

0.049

–

0.006

 PPARγC1β

0.49 (0.4–0.5)

0.41 (0.3–0.4)

0.41 (0.4–0.5)

–

–

–

 PTGS2

0.26 (0.2–0.3)

0.18 (0.2–0.2)

0.24 (0.2–0.3)

0.009

–

–

 TLR2

3.05 (2.1–3.5)

1.63 (1.4–2.8)

2.39 (1.6–2.8)

–

–

–

 TLR4

3.13 (2.4–3.8)

2.43 (2.1–3.2)

3.22 (2.5–3.9)

–

–

–

 TLR6

0.76 (0.7–1.1)

0.67 (0.5–0.7)

0.63 (0.6–0.9)

–

–

–

 SREBP1

1.04 (0.9–1.4)

0.78 (0.7–1.0)

1.09 (0.9–1.2)

–

–

–

 SCD1

0.29 (0.2–0.3)

0.23 (0.2–0.2)

0.29 (0.2–0.4)

–

–

–

 UCP2

31.77 (28.5–36.3)

27.38 (26.2–30.0)

36.41 (31.1–42.2)

0.041

–

0.003

Inflammation

 CD40

0.74 (0.7–1.1)

0.71 (0.6–0.9)

1.05 (0.8–1.3)

–

–

–

 CD8A

8.56 (6.3–16.2)

11.82 (7.5–17.3)

11.27 (9.1–13.9)

–

–

–

 CD3E

28.84 (23.4–33.3)

23.74 (22.4–26.2)

31.17 (25.0–32.7)

–

–

–

 CD40LG

1.76 (1.1–2.0)

1.62 (1.4–1.9)

1.76 (1.5–1.9)

–

–

–

 CXCL16

1.52 (1.4–2.2)

1.41 (1.1–1.6)

2.00 (1.5–2.2)

–

–

–

 FOXP3

0.30 (0.2–0.4)

0.25 (0.2–0.3)

0.36 (0.3–0.4)

–

–

–

 GATA3

3.49 (3.0–5.0)

3.10 (2.8–3.9)

3.80 (3.5–4.3)

–

–

–

 IFNγ

0.16 (0.1–0.3)

0.29 (0.2–0.5)

0.25 (0.2–0.4)

–

–

–

 IL1β

0.83 (0.7–1.5)

0.59 (0.5–0.8)

0.65 (0.6–1.0)

0.007

0.037

–

 IL4

ND

ND

ND

 IL8

ND

ND

ND

 IL18

0.26 (0.2–0.3)

0.19 (0.2–0.3)

0.23 (0.2–0.3)

–

–

–

 TBX21

4.49 (3.7–5.4)

6.32 (4.1–7.2)

5.79 (4.3–6.2)

–

–

–

 TGFB2

0.09 (0.1–0.2)

0.12 (0.1–0.3)

0.16 (0.1–0.2)

–

–

–

 TNF

1.52 (1.1–1.7)

1.34 (1.1–1.6)

1.42 (1.2–1.8)

–

–

–

Autophagi/ER stress

 BAG3

0.43 (0.3–0.5)

0.33 (0.2–0.4)

0.44 (0.4–0.5)

–

–

–

 SQSTM1

5.50 (4.9–6.4)

5.13 (4.3–5.3)

6.06 (5.0–6.5)

–

–

–

Markers associated with obesity

 CTSS

82.53 (68.8–123.6)

75.82 (64.2–97.6)

100.80 (76.3–114.6)

–

–

–

 F3

ND

ND

ND

 PLAT

ND

ND

ND

 TFPI

0.40 (0.3–0.8)

0.60 (0.5–0.8)

0.58 (0.6–0.9)

–

–

–

 RBP4

ND

ND

ND

 SERPINE

0.07 (0.1–0.1)

0.14 (0.1–0.2)

0.17 (0.1–0.2)

–

0.014

–