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Table 1 Covariates by case and control status and odds ratios (OR) for gastric cancer risk, EPIC-Eurgast study

From: Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort

 

Cases

Controls

ORa (95 % CI)

n = 365

%

n = 1,284

%

Age at recruitment

 Mean (SD)

58.4 (7.9)

 

58.4 (7.7)

 

Country

    

 France

2

0.5

3

0.2

 Italy

56

15.3

206

16

 Spain

41

11.2

134

10.4

 UK

41

11.2

135

10.5

 The Netherlands

26

7.1

99

7.7

 Greece

24

6.6

88

6.9

 Germany

48

13.2

186

14.5

 Sweden

64

17.5

220

17.1

 Denmark

61

16.7

205

16

 Norway

2

0.5

8

0.6

Sex

     

 Men

214

58.6

759

59.1

 Women

151

41.4

525

40.9

Smoking status

     

 Never

128

35.1

542

42.2

1.00 (Referent)

 Former

115

31.5

427

33.3

1.19 (0.88–1.61)

 Current

118

32.3

292

22.7

1.84 (1.36–2.50)

 Unknown

4

1.1

23

1.8

 

H. pylori infection at baseline

     

 Negative

68

18.8

492

38.7

1.00 (Referent)

 Positiveb

294

81.2

779

61.3

3.19 (2.35–4.33)

Plasma vitamin Cc (μmol/L, tertiles)

     

 <31

63

36.63

95

30.55

1.00 (Referent)

 31–44.9

55

31.98

107

34.41

0.74 (0.46–1.18)

 ≥45

54

31.4

109

35.05

0.70 (0.43–1.13)

Vitamin C intake from food sources (mg/d, tertiles)

     

 <86.76

148

40.55

435

33.88

1.00 (Referent)

 86.76–135.82

112

30.68

425

33.1

0.75 (0.57–1.00)

 ≥135.83

105

28.77

424

33.02

0.69 (0.51–0.93)

Processed meat intake (g/d, tertiles)

     

 <16.89

111

30.41

435

33.88

1.00 (Referent)

 16.89–39.57

108

29.59

424

33.02

1.05 (0.76–1.45)

 ≥39.58

146

40

425

33.1

1.58 (1.12–2.23)

  1. aAdjusted for age at recruitment (5-year categories), sex, and country
  2. b cagA-positive or anti-H. pylori positive, or both
  3. cPlasma vitamin C concentration assessed in a subset (172 cases and 311 controls)