Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort

Table 2 Multiple linear regression of log_e-transformed plasma vitamin C level and vitamin C transporter gene variants, in controls from the EPIC-Eurgast study

Gene, SNP^a	n = 311	Mean plasma vitamin C (μmol/L)	Model^b	β parameter	95 % CL	% Change in plasma vitamin C level (95 % CL)	Variant allele/genotype
SLC23A1
rs11950646
AA	125	42.01
AG	128	39.1	A	−0.11	−0.20, −0.017	−10 % (−2, −18 %)	G allele
GG	32	34	D	−0.14	−0.26, −0.011	−13 % (−1, −23 %)	AG + GG
rs33972313
GG	293	40.4
GA	17	33.65	C	−0.28	−0.54, −0.016	−24 % (−2, −42 %)	GA
AA	0	–
SLC23A2
rs6053005
CC	79	38.6
CT	151	39.39
TT	58	43.69	R	0.21	0.058, 0.37	+24 % (6, 44 %)	TT
rs6133175
AA	115	39.13
AG	139	39.42
GG	37	45.22	R	0.22	0.029, 0.40	+24 % (3, 50 %)	GG

Adjusted for age at recruitment (5-year categories), sex, country, smoking intensity, baseline H. pylori infection status, and season of blood draw
SNP single-nucleotide polymorphism, CL confidence limit
^a SLC23A1 and SLC23A2 variants not listed were not predictors of plasma vitamin C levels in multiple linear regression models (all β parameter P values > 0.10)
^bGenetic models: A allelic or log-additive, D dominant, R recessive, C codominant

ISSN: 1865-3499