Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort

Table 4 SLC23A1 and SLC23A2 haplotype frequencies and gastric cancer risk, EPIC-Eurgast study

Gene–haplotype	Cases	Controls	OR^a	95 % CI
SLC23A1 ^b
A G A G	0.61	0.6	1	Referent
G C G G	0.23	0.23	0.95	0.77–1.18
A C G G	0.081	0.084	0.81	0.58–1.13
Rare	0.08	0.08	–	–
SLC23A2 ^c
Block 1
C G C C	0.38	0.43	1	Referent
C G T C	0.33	0.29	1.29	1.04–1.60
A G C C	0.13	0.12	1.29	0.95–1.74
C G T G	0.1	0.1	1.07	0.78–1.45
Rare	0.058	0.052	–	–
Block 2
C C C G G	0.33	0.31	1	Referent
T C C G A	0.29	0.31	0.85	0.68–1.06
C C C G A	0.13	0.13	0.93	0.70–1.24
C C T C A	0.11	0.1	1.01	0.74–1.38
C T T C A	0.06	0.07	0.94	0.65–1.37
Rare	0.078	0.091	–	–
Block 3
A T T	0.32	0.34	1	Referent
T C C	0.3	0.32	1.05	0.84–1.30
T C T	0.12	0.11	1.18	0.86–1.63
A T C	0.11	0.093	1.44	1.01–2.05
A C T	0.094	0.11	1.07	0.77–1.49
Rare	0.044	0.028	–	–
Block 4
G C G	0.58	0.59	1	Referent
G C A	0.24	0.24	1.17	0.95–1.44
T C G	0.12	0.12	1.06	0.81–1.39
Rare	0.05	0.049	–	–

^aHaplotype odds ratios (OR) adjusted for age at recruitment (5-year categories), sex, country, smoking status, baseline H. pylori infection status, and season of blood draw
^bInferred using rs659671, rs6596473, rs17339746 and rs33972313
^cInferred using rs6052937, rs3787456, rs6116569, rs17339746 (block 1); rs6052961, rs17339942, rs1776963, rs1715380, rs6133175 (block 2); rs6139587, rs6053005, rs2326576 (block 3); rs6053034, rs8126456, rs1279685 (block 4)

ISSN: 1865-3499