From: Genetic modulation of the serotonergic pathway: influence on weight reduction and weight maintenance
 | Total (n = 135) | Female (n = 85) | Male (n = 50) | ||||||
---|---|---|---|---|---|---|---|---|---|
SS | SL & LL | p | SS | SL & LL | p | SS | SL & LL | p | |
Fraction (n [%]) | 29 [21.5] | 106 [78.5] | Â | 20 [23.5] | 65 [76.5] | Â | 9 [18] | 41 [82] | Â |
Age (years) | 48 ± 10 | 46 ± 13 | 0.32* | 49 ± 10 | 44 ± 13 | 0.13* | 48 ± 10 | 48 ± 12 | 0.82* |
Nicotine use (n [%]) | 4 [13.8] | 19 [17.9] | 0.57†| 4 [20] | 13 [20] | 0.95†| 0 [0] | 6 [14.6] | 0.22†|
Systolic blood pressure (mmHg) | 142.7 ± 15.4 | 140.0 ± 18.5 | 0.39* | 138.2 ± 13.2 | 138.7 ± 17.8 | 0.99* | 152.8 ± 15.8 | 142.1 ± 19.5 | 0.07* |
Diastolic blood pressure (mmHg) | 87.1 ± 9.1 | 88.5 ± 11.3 | 0.42* | 84.4 ± 6.2 | 89.1 ± 12.4 | 0.11* | 93.2 ± 11.8 | 87.5 ± 9.4 | 0.28* |
Glucose (mg/dL) | 107.0 ± 21.4 | 110.0 ± 28.8 | 0.79* | 106.2 ± 22.3 | 104.9 ± 22.7 | 0.72* | 108.8 ± 20.6 | 118.5 ± 35.5 | 0.38* |
Total cholesterol (mg/dL) | 213.9 ± 42.0 | 204.4 ± 39.9 | 0.29* | 210.0 ± 46.5 | 201.4 ± 37.1 | 0.51* | 222.7 ± 30.2 | 209.3 ± 44.1 | 0.38* |
LDL cholesterol (mg/dL) | 133.7 ± 37.6 | 124.6 ± 32.2 | 0.35* | 134.1 ± 40.5 | 124.6 ± 31.0 | 0.44* | 132.9 ± 31.7 | 124.6 ± 34.6 | 0.62* |
HDL cholesterol (mg/dL) | 52.6 ± 11.0 | 48.9 ± 12.4 | 0.09* | 54.6 ± 10.8 | 51.7 ± 13.2 | 0.19* | 48 ± 10.5 | 44.2 ± 9.4 | 0.33* |
Triacylglycerols (mg/dL) | 129.3 ± 68.6 | 153.3 ± 88.2 | 0.28* | 106.3 ± 44.3 | 126.6 ± 46.0 | 0.10* | 186.9 ± 86.7 | 197.3 ± 119.2 | 0.51* |
Weight (kg) T0 | 119.1 ± 15.9 | 125.3 ± 22.8 | 0.26* | 114.7 ± 14.9 | 118.7 ± 19.5 | 0.43* | 128.9 ± 14.2 | 135.7 ± 24 | 0.50* |
BMI (kg/m²) T0 | 40.9 ± 5.1 | 42.1 ± 6.4 | 0.50* | 40.9 ± 5.1 | 41.9 ± 6.2 | 0.65* | 40.8 ± 5.3 | 42.4 ± 6.9 | 0.73* |
Weight (kg) T2 | 99.4 ± 16.6 | 101.8 ± 21.1 | 0.77* | 97.9 ± 18.2 | 97.9 ± 17.8 | 0.91* | 102.6 ± 12.9 | 108.1 ± 24.5 | 0.83* |
BMI (kg/m²) T2 | 34.1 ± 5.8 | 34.3 ± 6.5 | 0.85* | 34.9 ± 6.2 | 34.6 ± 5.9 | 0.87* | 32.5 ± 4.6 | 33.8 ± 7.4 | 0.95* |
Weight (kg) T0–2 | −19.8 ± 10.8 | −23.5 ± 12.1 | 0.11* | −16.9 ± 9.7 | −20.8 ± 9.8 | 0.07* | −26.2 ± 10.8 | −27.7 ± 14.2 | 0.73* |
BMI (kg/m²) T0–2 | −6.7 ± 3.5 | −7.8 ± 3.8 | 0.17* | −6.0 ± 3.4 | −7.3 ± 3.4 | 0.10* | −8.3 ± 3.4 | −8.6 ± 4.3 | 0.92* |
Weight (kg) T0–1 | −18.5 ± 5.4 | −20.3 ± 5.9 | 0.12* | −16.7 ± 3.1 | −18.2 ± 4.6 | 0.18* | −22.4 ± 7.5 | −23.7 ± 6.3 | 0.52* |
BMI (kg/m²) T0–1 | −6.3 ± 1.7 | −6.8 ± 1.7 | 0.14* | −5.9 ± 1.0 | −6.4 ± 1.6 | 0.23* | −7.1 ± 2.4 | −7.4 ± 1.8 | 0.63* |
Weight (kg) T1–2 | −1.3 ± 9.4 | −3.1 ± 8.9 | 0.30* | −0.2 ± 9.4 | −2.6 ± 7.5 | 0.13* | −3.8 ± 9.2 | −4.0 ± 10.7 | 0.82* |
BMI (kg/m²) T1–2 | −0.4 ± 3.1 | −1.0 ± 2.9 | 0.34* | −0.1 ± 3.3 | −0.9 ± 2.6 | 0.15* | −1.2 ± 2.8 | −1.3 ± 3.3 | 0.80* |