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Table 1 Baseline characteristics and weight loss of all completers according to the 5-HTTLPR polymorphism

From: Genetic modulation of the serotonergic pathway: influence on weight reduction and weight maintenance

 

Total (n = 135)

Female (n = 85)

Male (n = 50)

SS

SL & LL

p

SS

SL & LL

p

SS

SL & LL

p

Fraction (n [%])

29 [21.5]

106 [78.5]

 

20 [23.5]

65 [76.5]

 

9 [18]

41 [82]

 

Age (years)

48 ± 10

46 ± 13

0.32*

49 ± 10

44 ± 13

0.13*

48 ± 10

48 ± 12

0.82*

Nicotine use (n [%])

4 [13.8]

19 [17.9]

0.57†

4 [20]

13 [20]

0.95†

0 [0]

6 [14.6]

0.22†

Systolic blood pressure (mmHg)

142.7 ± 15.4

140.0 ± 18.5

0.39*

138.2 ± 13.2

138.7 ± 17.8

0.99*

152.8 ± 15.8

142.1 ± 19.5

0.07*

Diastolic blood pressure (mmHg)

87.1 ± 9.1

88.5 ± 11.3

0.42*

84.4 ± 6.2

89.1 ± 12.4

0.11*

93.2 ± 11.8

87.5 ± 9.4

0.28*

Glucose (mg/dL)

107.0 ± 21.4

110.0 ± 28.8

0.79*

106.2 ± 22.3

104.9 ± 22.7

0.72*

108.8 ± 20.6

118.5 ± 35.5

0.38*

Total cholesterol (mg/dL)

213.9 ± 42.0

204.4 ± 39.9

0.29*

210.0 ± 46.5

201.4 ± 37.1

0.51*

222.7 ± 30.2

209.3 ± 44.1

0.38*

LDL cholesterol (mg/dL)

133.7 ± 37.6

124.6 ± 32.2

0.35*

134.1 ± 40.5

124.6 ± 31.0

0.44*

132.9 ± 31.7

124.6 ± 34.6

0.62*

HDL cholesterol (mg/dL)

52.6 ± 11.0

48.9 ± 12.4

0.09*

54.6 ± 10.8

51.7 ± 13.2

0.19*

48 ± 10.5

44.2 ± 9.4

0.33*

Triacylglycerols (mg/dL)

129.3 ± 68.6

153.3 ± 88.2

0.28*

106.3 ± 44.3

126.6 ± 46.0

0.10*

186.9 ± 86.7

197.3 ± 119.2

0.51*

Weight (kg) T0

119.1 ± 15.9

125.3 ± 22.8

0.26*

114.7 ± 14.9

118.7 ± 19.5

0.43*

128.9 ± 14.2

135.7 ± 24

0.50*

BMI (kg/m²) T0

40.9 ± 5.1

42.1 ± 6.4

0.50*

40.9 ± 5.1

41.9 ± 6.2

0.65*

40.8 ± 5.3

42.4 ± 6.9

0.73*

Weight (kg) T2

99.4 ± 16.6

101.8 ± 21.1

0.77*

97.9 ± 18.2

97.9 ± 17.8

0.91*

102.6 ± 12.9

108.1 ± 24.5

0.83*

BMI (kg/m²) T2

34.1 ± 5.8

34.3 ± 6.5

0.85*

34.9 ± 6.2

34.6 ± 5.9

0.87*

32.5 ± 4.6

33.8 ± 7.4

0.95*

Weight (kg) T0–2

−19.8 ± 10.8

−23.5 ± 12.1

0.11*

−16.9 ± 9.7

−20.8 ± 9.8

0.07*

−26.2 ± 10.8

−27.7 ± 14.2

0.73*

BMI (kg/m²) T0–2

−6.7 ± 3.5

−7.8 ± 3.8

0.17*

−6.0 ± 3.4

−7.3 ± 3.4

0.10*

−8.3 ± 3.4

−8.6 ± 4.3

0.92*

Weight (kg) T0–1

−18.5 ± 5.4

−20.3 ± 5.9

0.12*

−16.7 ± 3.1

−18.2 ± 4.6

0.18*

−22.4 ± 7.5

−23.7 ± 6.3

0.52*

BMI (kg/m²) T0–1

−6.3 ± 1.7

−6.8 ± 1.7

0.14*

−5.9 ± 1.0

−6.4 ± 1.6

0.23*

−7.1 ± 2.4

−7.4 ± 1.8

0.63*

Weight (kg) T1–2

−1.3 ± 9.4

−3.1 ± 8.9

0.30*

−0.2 ± 9.4

−2.6 ± 7.5

0.13*

−3.8 ± 9.2

−4.0 ± 10.7

0.82*

BMI (kg/m²) T1–2

−0.4 ± 3.1

−1.0 ± 2.9

0.34*

−0.1 ± 3.3

−0.9 ± 2.6

0.15*

−1.2 ± 2.8

−1.3 ± 3.3

0.80*

  1. T0: start of the program, T1: after weight reduction phase, T2: after weight maintenance phase and end of the program
  2. Mean values ± SD and p values are given
  3. * Mann–Whitney U test; † χ 2 test