From: Genetic modulation of the serotonergic pathway: influence on weight reduction and weight maintenance
 | Total (n = 130) | Female (n = 81) | Male (n = 49) | ||||||
---|---|---|---|---|---|---|---|---|---|
3R | 3/4R & 4/4R | p | 3R | 3/4R & 4/4R | p | 3R | 4R | p | |
Fraction (n [%]) | 34 [26.2] | 96 [73.8] | Â | 14 [17.3] | 67 [82.7] | Â | 20 [40.8] | 29 [59.2] | Â |
Age (years) | 49 ± 11 | 45 ± 12 | 0.10* | 48 ± 9 | 45 ± 12 | 0.35* | 50 ± 13 | 46 ± 12 | 0.25* |
Nicotine use (n [%]) | 6 [17.6] | 17 [17.7] | 0.97†| 3 [21.4] | 14 [20.9] | 0.99†| 3 [6.1] | 3 [10.4] | 0.63†|
Systolic blood pressure (mmHg) | 145.3 ± 19.6 | 138.9 ± 17.4 | 0.13* | 140.1 ± 16.7 | 137.9 ± 17.3 | 0.68* | 149.0 ± 21.0 | 141.2 ± 17.6 | 0.24* |
Diastolic blood pressure (mmHg) | 88.5 ± 9.5 | 87.7 ± 11.0 | 0.74* | 86.2 ± 5.5 | 87.7 ± 11.8 | 0.75* | 90.2 ± 11.4 | 87.8 ± 9.0 | 0.65* |
Glucose (mg/dL) | 117.8 ± 33.9 | 105.5 ± 23.3 | 0.05* | 112.5 ± 26.4 | 102.1 ± 19.5 | 0.22* | 121.5 ± 38.5 | 113.9 ± 29.6 | 0.64* |
Total cholesterol (mg/dL) | 204.1 ± 42.1 | 208.6 ± 39.6 | 0.67* | 194.6 ± 41.8 | 206.6 ± 38.1 | 0.27* | 210.7 ± 42.0 | 213.3 ± 43.2 | 0.97* |
LDL cholesterol (mg/dL) | 122.7 ± 34.4 | 128.5 ± 33 | 0.38* | 120.0 ± 33.3 | 128.9 ± 33.0 | 0.37* | 125.0 ± 36.2 | 127.4 ± 33.6 | 0.82* |
HDL cholesterol(mg/dL) | 47.3 ± 11.2 | 50.9 ± 12.5 | 0.14* | 50.1 ± 12.2 | 53.6 ± 12.8 | 0.18* | 45.3 ± 10.2 | 44.4 ± 9.3 | 0.50* |
Triacylglycerols (mg/dL) | 163.3 ± 99.1 | 143.1 ± 80.4 | 0.35* | 123.0 ± 46.8 | 120.3 ± 45.1 | 0.88* | 194.6 ± 117.7 | 197.6 ± 114.8 | 0.87* |
Weight (kg) T0 | 128 ± 17.6 | 123 ± 23.0 | 0.08* | 119.6 ± 15.9 | 117.7 ± 19.3 | 0.62* | 133.8 ± 16.7 | 135.3 ± 26.4 | 0.74* |
BMI (kg/m²) T0 | 42.3 ± 4.6 | 41.7 ± 6.7 | 0.29* | 43.1 ± 3.6 | 41.4 ± 6.4 | 0.14* | 41.7 ± 5.2 | 42.5 ± 7.5 | 0.92* |
Weight (kg) T2 | 105.5 ± 16.9 | 100.3 ± 21.4 | 0.06* | 103.3 ± 17.1 | 97.0 ± 18.0 | 0.15* | 107.1 ± 17.1 | 107.9 ± 26.4 | 0.95* |
BMI (kg/m²) T2 | 34.9 ± 5.3 | 34.0 ± 6.6 | 0.23* | 37.2 ± 4.7 | 34.1 ± 6.1 | 0.03* | 33.4 ± 5.3 | 33.9 ± 7.9 | 0.79* |
Weight (kg) T0–2 | −22.5 ± 12.4 | −22.8 ± 11.9 | 0.85* | −16.4 ± 10.9 | −20.8 ± 9.7 | 0.07* | −26.8 ± 11.8 | −27.4 ± 14.9 | 0.99* |
BMI (kg/m²) T0–2 | −7.3 ± 3.8 | −7.7 ± 3.8 | 0.61* | −5.9 ± 3.8 | −7.3 ± 3.4 | 0.10* | −8.3 ± 3.6 | −8.6 ± 4.5 | 0.95* |
Weight (kg) T0–1 | −21.5 ± 7.0 | −19.5 ± 5.4 | 0.14* | −17.4 ± 4.8 | −18.1 ± 4.4 | 0.54* | −24.3 ± 7.0 | −22.8 ± 6.2 | 0.30* |
BMI (kg/m²) T0–1 | −7.0 ± 2.0 | −6.6 ± 1.6 | 0.22* | −6.2 ± 1.5 | −6.3 ± 1.5 | 0.96* | −7.6 ± 2.2 | −7.2 ± 1.8 | 0.34* |
Weight (kg) T1–2 | −1.0 ± 9.4 | −3.3 ± 8.8 | 0.26* | +1.0 ± 10.0 | −2.7 ± 7.6 | 0.09* | −2.5 ± 9.0 | −4.6 ± 11.2 | 0.75* |
BMI (kg/m²) T1–2 | −0.3 ± 3.1 | −1.1 ± 2.9 | 0.22* | +0.3 ± 3.5 | −1.0 ± 2.7 | 0.10* | −0.8 ± 2.8 | −1.4 ± 3.5 | 0.72* |