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Table 2 Baseline characteristics and weight loss of all completers according to the MAOA uVNTR polymorphism

From: Genetic modulation of the serotonergic pathway: influence on weight reduction and weight maintenance

 

Total (n = 130)

Female (n = 81)

Male (n = 49)

3R

3/4R & 4/4R

p

3R

3/4R & 4/4R

p

3R

4R

p

Fraction (n [%])

34 [26.2]

96 [73.8]

 

14 [17.3]

67 [82.7]

 

20 [40.8]

29 [59.2]

 

Age (years)

49 ± 11

45 ± 12

0.10*

48 ± 9

45 ± 12

0.35*

50 ± 13

46 ± 12

0.25*

Nicotine use (n [%])

6 [17.6]

17 [17.7]

0.97†

3 [21.4]

14 [20.9]

0.99†

3 [6.1]

3 [10.4]

0.63†

Systolic blood pressure (mmHg)

145.3 ± 19.6

138.9 ± 17.4

0.13*

140.1 ± 16.7

137.9 ± 17.3

0.68*

149.0 ± 21.0

141.2 ± 17.6

0.24*

Diastolic blood pressure (mmHg)

88.5 ± 9.5

87.7 ± 11.0

0.74*

86.2 ± 5.5

87.7 ± 11.8

0.75*

90.2 ± 11.4

87.8 ± 9.0

0.65*

Glucose (mg/dL)

117.8 ± 33.9

105.5 ± 23.3

0.05*

112.5 ± 26.4

102.1 ± 19.5

0.22*

121.5 ± 38.5

113.9 ± 29.6

0.64*

Total cholesterol (mg/dL)

204.1 ± 42.1

208.6 ± 39.6

0.67*

194.6 ± 41.8

206.6 ± 38.1

0.27*

210.7 ± 42.0

213.3 ± 43.2

0.97*

LDL cholesterol (mg/dL)

122.7 ± 34.4

128.5 ± 33

0.38*

120.0 ± 33.3

128.9 ± 33.0

0.37*

125.0 ± 36.2

127.4 ± 33.6

0.82*

HDL cholesterol(mg/dL)

47.3 ± 11.2

50.9 ± 12.5

0.14*

50.1 ± 12.2

53.6 ± 12.8

0.18*

45.3 ± 10.2

44.4 ± 9.3

0.50*

Triacylglycerols (mg/dL)

163.3 ± 99.1

143.1 ± 80.4

0.35*

123.0 ± 46.8

120.3 ± 45.1

0.88*

194.6 ± 117.7

197.6 ± 114.8

0.87*

Weight (kg) T0

128 ± 17.6

123 ± 23.0

0.08*

119.6 ± 15.9

117.7 ± 19.3

0.62*

133.8 ± 16.7

135.3 ± 26.4

0.74*

BMI (kg/m²) T0

42.3 ± 4.6

41.7 ± 6.7

0.29*

43.1 ± 3.6

41.4 ± 6.4

0.14*

41.7 ± 5.2

42.5 ± 7.5

0.92*

Weight (kg) T2

105.5 ± 16.9

100.3 ± 21.4

0.06*

103.3 ± 17.1

97.0 ± 18.0

0.15*

107.1 ± 17.1

107.9 ± 26.4

0.95*

BMI (kg/m²) T2

34.9 ± 5.3

34.0 ± 6.6

0.23*

37.2 ± 4.7

34.1 ± 6.1

0.03*

33.4 ± 5.3

33.9 ± 7.9

0.79*

Weight (kg) T0–2

−22.5 ± 12.4

−22.8 ± 11.9

0.85*

−16.4 ± 10.9

−20.8 ± 9.7

0.07*

−26.8 ± 11.8

−27.4 ± 14.9

0.99*

BMI (kg/m²) T0–2

−7.3 ± 3.8

−7.7 ± 3.8

0.61*

−5.9 ± 3.8

−7.3 ± 3.4

0.10*

−8.3 ± 3.6

−8.6 ± 4.5

0.95*

Weight (kg) T0–1

−21.5 ± 7.0

−19.5 ± 5.4

0.14*

−17.4 ± 4.8

−18.1 ± 4.4

0.54*

−24.3 ± 7.0

−22.8 ± 6.2

0.30*

BMI (kg/m²) T0–1

−7.0 ± 2.0

−6.6 ± 1.6

0.22*

−6.2 ± 1.5

−6.3 ± 1.5

0.96*

−7.6 ± 2.2

−7.2 ± 1.8

0.34*

Weight (kg) T1–2

−1.0 ± 9.4

−3.3 ± 8.8

0.26*

+1.0 ± 10.0

−2.7 ± 7.6

0.09*

−2.5 ± 9.0

−4.6 ± 11.2

0.75*

BMI (kg/m²) T1–2

−0.3 ± 3.1

−1.1 ± 2.9

0.22*

+0.3 ± 3.5

−1.0 ± 2.7

0.10*

−0.8 ± 2.8

−1.4 ± 3.5

0.72*

  1. T0: start of the program, T1: after weight reduction phase, T2: after weight maintenance phase and end of the program
  2. Mean values ± SD and p values are given. Significant p values (p ≤ 0.05) are standing out in bold
  3. * Mann–Whitney U test; † χ 2 test