Skip to main content

Table 1 Distribution of genotypes between patients and controls

From: Association of genetic variants of ghrelin, leptin and UCP2 with malnutrition inflammation syndrome and survival in end-stage renal disease patients

Marker

Genotype

Patient

Control

OR (95 % CI)

P value

UCP2 I/D

 

DD

149 (57.6 %)

94 (47.0 %)

Reference

 
 

ID

70 (27.6 %)

82 (41.0 %)

0.5 (0.3–0.8)

0.003*

 

II

38 (14.8 %)

24 (12.0 %)

1.3 (0.7–2.2)

0.4

 

D

368 (71.6 %)

270 (67.5 %)

Reference

 
 

I

146 (28.4 %)

130 (32.5 %)

1.2 (0.9–1.6)

0.2

Dominant model

 

DD versus II + ID

  

1.2 (0.8–1.7)

0.2

Recessive model

 

II versus ID + DD

  

0.7 (0.45–1.3)

0.4

Leptin-2548 G/A

 

GG

90 (35.0 %)

82 (41.0 %)

Reference

 
 

GA

99 (38.5 %)

92 (46.0 %)

1.2 (0.8–1.9)

0.39

 

AA

68 (26.5 %)

26 (13.0 %)

2.0 (1.2–3.3)

0.007*

 

G

279 (54.3 %)

256 (64.0 %)

Reference

 
 

A

235 (45.7 %)

144 (36.0 %)

1.5 (1.1–1.9)

0.003*

Dominant model

 

GG versus GA + AA

  

0.27 (0.1–0.4)

0.001*

Recessive model

 

AA vs. GG + GA

  

1.8 (1.1–2.9)

0.012*

Ghrelin Arg51Gln

 

GG

164 (63.8 %)

142 (71.0 %)

Reference

 
 

GA

75 (29.2 %)

53 (26.5 %)

1.2 (0.8–1.8)

0.33

 

AA

18 (7.0 %)

5 (2.5 %)

3.4 (1.2–7.5)

0.02*

 

G

403 (78.4 %)

337 (84.3 %)

Reference

 
 

A

111 (21.6 %)

63 (15.7 %)

1.6 (1.1–2.1)

0.02*

Dominant model

 

GG versus GA + AA

  

0.7 (0.4–1.0)

0.1

Recessive model

 

AA versus GG + GA

  

2.9 (1.0–8.0)

0.003*

Ghrelin Leu72Met

 

CC

178 (69.3 %)

141 (70.5 %)

Reference

 
 

CA

51 (19.8 %)

50 (25.0 %)

0.8 (0.5–1.3)

0.2

 

AA

28 (10.9 %)

9 (4.5 %)

2.5 (1.2–5.4)

0.02*

 

C

407 (79.2 %)

332 (83.0 %)

Reference

 
 

A

107 (20.8 %)

68 (17.0 %)

1.3 (0.9–1.8)

0.15

Dominant model

 

CC versus CA + AA

  

1.07 (0.7–1.6)

0.75

Recessive model

 

AA versus CC + CA

  

2.58 (1.2–5.6)

0.01*

  1. Logistic regression analysis was used for comparing the genotypes