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Table 2 Comparison of genotype among patients on the basis of SGA scores

From: Association of genetic variants of ghrelin, leptin and UCP2 with malnutrition inflammation syndrome and survival in end-stage renal disease patients

Genotype

Normal

Mild

Moderate

Severe

Normal versus mild

OR (95 % CI), P

Normal versus moderate

OR (95 % CI), P

Normal versus severe

OR (95 % CI), P

UCP2 I/D

DD

47 (60.2 %)

22 (58.0 %)

56 (56.0 %)

24 (58.5 %)

Reference

Reference

Reference

ID

22 (28.2 %)

8 (21.0 %)

31 (31.0 %)

9 (22.0 %)

0.7 (0.2–2.0), 0.6

1.1 (0.6–2.3), 0.6

0.8 (0.3–2.0), 0.6

II

9 (11.5 %)

8 (21.0 %)

13 (13.0 %)

8 (19.5 %)

1.9 (0.6–5.5), 0.2

1.2 (0.4–3.08), 0.7

1.7 (0.5–5.0), 0.3

D

116 (74.3 %)

52 (68.4 %)

143 (71.5 %)

57 (69.5 %)

Reference

Reference

Reference

I

40 (25.7 %)

24 (31.6 %)

57 (28.5 %)

25 (30.5 %)

1.2 (0.7–2.3), 0.4

1.1 (0.69–1.79), 0.7

1.2 (0.68–2.2), 0.5

Leptin-2548 G/A

GG

26 (33.3 %)

11 (28.9 %)

38 (38.0 %)

15 (36.5 %)

Reference

Reference

Reference

GA

31 (39.7 %)

16 (42.1 %)

37 (37.0 %)

15 (36.5 %)

0.9 (0.4–1.9), 0.8

1.1 (0.6–2.0), 0.7

0.8 (0.4–1.9), 0.8

AA

21 (26.9 %)

11 (28.9 %)

25 (25.0 %)

11 (26.8 %)

0.9 (0.3–2.1), 0.8

1.1 (0.5–2.1), 0.8

1.0 (0.4–2.3), 1.0

G

83 (53.4 %)

38 (50.0 %)

113 (56.5 %)

45 (54.8 %)

Reference

Reference

Reference

A

73 (46.7 %)

38 (50.0 %)

87 (43.5 %)

37 (45.2 %)

1.1 (0.6–1.9), 0.6

0.8 (0.5–1.3), 0.6

0.9 (0.5–1.5), 0.8

Ghrelin Arg51Gln

GG

50 (64.1 %)

22 (57.9 %)

73 (73.0 %)

19 (46.3 %)

Reference

Reference

Reference

GA

24 (30.8 %)

13 (34.2 %)

23 (23.0 %)

15 (36.6 %)

1.2 (0.5–2.6), 0.8

0.7 (0.3–1.3), 0.3

1.3 (0.5–2.8), 0.5

AA

4 (5.1 %)

3 (7.8 %)

4 (4.0 %)

7 (17.1 %)

1.6 (0.3–7.4), 0.6

0.8 (0.2–3.2), 0.7

3.3 (1.2–13.8), 0.04

G

124 (79.5 %)

57 (75.0 %)

169 (84.5 %)

53 (64.3 %)

Reference

Reference

Reference

A

32 (29.5 %)

19 (25.0 %)

31 (15.5 %)

29 (35.7 %)

1.3 (0.7–2.4), 0.5

0.6 (0.3–1), 0.1

2.1 (1.1–3.8), 0.02*

Ghrelin Leu72Met

CC

63 (80.8 %)

22 (65.8 %)

72 (72.0 %)

21 (51.2 %)

Reference

Reference

Reference

CA

11 (14.1 %)

10 (26.3 %)

16 (16.0 %)

14 (34.1 %)

2.6 (1.1–6.9), 0.04*

1.2 (0.5–2.9), 0.5

3.8 (1.5–7.6), 0.005*

AA

4 (5.1 %)

6 (7.9 %)

12 (12.0 %)

6 (14.7 %)

4.2 (1.1–16), 0.03

2.6 (0.8–8.5), 0.1

4.5 (1.1–10.5), 0.03

C

137 (87.8 %)

54 (79.0 %)

160 (80.0 %)

56 (68.3 %)

Reference

Reference

Reference

A

19 (12.2 %)

22 (21.0 %)

40 (20.0 %)

26 (31.7 %)

1.9 (0.9–3.9), 0.08

1.8 (0.9–3.25), 0.06

3.3 (1.7–6.5), 0.004*

  1. * P ≤ 0.05 significant, values in parenthesis are % frequencies, normal SGA category was taken as reference for comparison with other SGA categories by logistic regression
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Genes & Nutrition

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