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Fig. 5 | Genes & Nutrition

Fig. 5

From: Vitamin D receptor BsmI polymorphism modulates soy intake and 25-hydroxyvitamin D supplementation benefits in cardiovascular disease risk factors profile

Fig. 5

Homeostatic regulation of vitamin D metabolites controlled by VDR and the influence of VDR polymorphism BsmI transcriptional activity. Soy compounds together with higher plasma amounts of 25(OH)D3 may induce a higher conversion of the activated form of vitamin D (1). The increase in 1α,25(OH)2D3, recognized by the VDR (2), reduction in the expression of CYP27B1 and increase in the expression of CYP24 (3) modifying the plasma levels of 1α,25(OH)2D3 and 24R,25(OH)2D3 (4). This homeostatic regulation is not effective in volunteers of the G allele BsmI polymorphism, which is recognized to induce a low-stability RNA and therefore changes in the VDR activity. In this context, the increase in 1α,25(OH)2D3 induced by soy compounds and vitamin D (5) is not effectively regulated by VDR (6), suggesting that the expression of the CYP27B1 and CYP24 enzymes are not controlled (7), inducing higher plasma levels of 1α,25(OH)2D3 (8)

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Genes & Nutrition

ISSN: 1865-3499

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