Effects of methionine synthase and methylenetetrahydrofolate reductase gene polymorphisms on markers of one-carbon metabolism

Table 3 Adjusted mean concentrations of HCY, SAM and SAH associated with the main effects of MTR and MTHFR polymorphisms

	N	μHCY μmol/L (95 % CI)^a	μSAM nmol/L (95 % CI)^b	μSAH nmol/L (95 % CI)^c
MTR
AA	363	9.2 (8.9, 9.5)	64.0 (62.1, 66.0)	25.9 (24.6, 27.2)
GA+GG	207	8.7 (8.3, 9.0)	63.4 (61.2, 65.7)	25.8 (24.1, 27.4)
p value^d		<0.01	0.57	0.88
MTHFR
CC	234	8.8 (8.5, 9.2)	64.6 (62.5–66.8)	26.6 (25.0–28.1)
CT	251	9.1 (8.8, 9.5)	63.0 (60.9–65.2)	25.4 (23.9–26.9)
TT	81	9.5 (9.0, 10.0)	64.0 (60.9–67.0)	24.9 (22.5–27.3)
p value^d		0.04	0.35	0.35

^a N = 570 for analysis with MTR; N = 566 for analysis with MTHFR; predictors of HCY (expressed in μmol/L) include age, sex, BMI, smoking, calcium, ratio of cholesterol to HDL, albumin, creatinine, folate and vitamin B₁₂
^b N = 565 for analysis with MTR; N = 561 for analysis with MTHFR; predictors of SAM (expressed in nmol/L) include age, BMI, alcohol consumption, tea consumption, creatinine, triglycerides, ethnicity and vitamin B₁₂
^c N = 565 for analysis with MTR; N = 561 for analysis with MTHFR; predictors of SAH (expressed in nmol/L) include age, sex, BMI and creatinine
^dTwo-sided p values based on F test

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