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Table 4 Multivariate analysis on mean SAH concentrations associated with the interaction of MTR and MTHFR polymorphisms

From: Effects of methionine synthase and methylenetetrahydrofolate reductase gene polymorphisms on markers of one-carbon metabolism

 

N

MTR ‘AA’

N

MTR ‘GA+GG’

P Interaction

μSAH (95 % CI)a

μSAH (95 % CI)a

MTHFR

 CC

156

25.5 (23.8, 27.3)

76

28.7 (26.2, 31.1)

0.01

 CT

152

25.9 (24.0, 27.8)

96

24.6 (22.3, 26.8)

 

 TT

48

26.7 (23.6, 29.7)

33

22.4 (18.8, 26.0)

 
  1. a N = 561; predictors of SAH (expressed in nmol/L) include age, sex, BMI and creatinine