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Table 5 Adjusted mean concentration of SAH (95 % CI) according to MTR and MTHFR genotypes and serum folate level

From: Effects of methionine synthase and methylenetetrahydrofolate reductase gene polymorphisms on markers of one-carbon metabolism

  

Serum folate ≤25th percentile

 

Serum folate >25th percentile

P Interaction

μSAH (95 % CI)a

 

μSAH (95 % CI)a

MTR

 AA

95

26.7 (24.5–29.0)

265

25.5 (24.0–27.0)

0.72

 GA+GG

45

27.3 (24.2, 30.3)

160

25.2 (23.4, 27.1)

 

MTHFR

 CC

47

30.3 (27.3–33.4)

185

25.6 (23.9–27.3)

0.02

 CT

67

26.1 (23.5–28.6)

181

25.2 (23.4–26.9)

 

 TT

24

22.4 (18.2–26.6)

57

26.0 (23.2–28.9)

 
  1. a N = 565 for analysis with MTR; N = 561 for analysis with MTHFR; predictors of SAH (expressed in nmol/L) include age, sex, BMI and creatinine
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Genes & Nutrition

ISSN: 1865-3499

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