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Table 5 Multivariable-adjusted means and differences (95 % CI) for the association between the SNPs and cognitive assessment according to intervention status

From: Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial

 

Mini-Mental State Examination

Clock Drawing Test

B (95 % CI)a

p value

p for interactionb

B (95 % CI)a

p value

p for interactionb

APOE

  

0.665

  

0.091

 E2 carriers (32)

0.44 (−0.29 to 1.17)

0.241

 

0.25 (−0.27 to 0.77)

0.348

 

 E3/E3 (401)

0 (Ref.)

  

0 (Ref.)

  

 E4 carriers (74)

−0.96 (−1.47 to −0.45)

<0.001d

 

−0.50 (−0.87 to −0.14)

0.007d

 

Non-E4 carriers

      

 Control (Low-fat diet) (108)

0 (Ref.)

  

0 (Ref.)

  

 Intervention (MedDietc) (325)

0.56 (0.15 to 0.97)

0.007d

 

0.55 (0.25 to 0.85)

<0.001d

 

E4 carriers

      

 Control (Low-fat diet) (20)

0 (Ref.)

  

0 (Ref.)

  

 Intervention (MedDietc) (54)

1.61 (0.10 to 3.13)

0.037

 

0.33 (−0.60 to 1.27)

0.477

 
  1. The numbers in parentheses are the subjects with this genotype
  2. MMSE Mini-Mental State Examination, CDT Clock Drawing Test, Ref. Advert this is the reference group
  3. aGeneral linear models adjusted for sex, age, education, family history of cognitive impairment or dementia, hypertension, dyslipidemia, diabetes, smoking status, alcohol intake, body mass index, physical activity and total energy intake. B represents the difference in points with the reference group
  4. bLikelihood ratio test: SNP (dominant model)*intervention status, adjusted for sex, age, education, ApoE genotype, family history of cognitive decline and BMI (kg/m2)
  5. cIntervention group gathers MedDiet intervention groups, MedDiet + EVOO (extra-virgin olive oil) and MedDiet + Nuts as it has been stated in the methods
  6. d p value < 0.05 after Benjamini–Hochberg multiple comparison adjustment