Skip to main content

Table 2 Metabolic markers before and after the intervention in the two groups receiving either fish oil or sunflower oil from 9 to 18 months of age

From: Effects on metabolic markers are modified by PPARG2 and COX2 polymorphisms in infants randomized to fish oil

 

n

FO group

SO group

p

p adj

FO/SO

9 months

18 months

Δ9–18 months

9 months

18 months

Δ9–18 months

Systolic blood pressure (mmHg)

53/56

111 ± 13

113 ± 12

2 ± 16

112 ± 9

115 ± 11

4 ± 14

0.282

0.296a

Diastolic blood pressure (mmHg)

52/56

66 ± 9

66 ± 9

0.2 ± 11

64 ± 8

66 ± 10

2 ± 13

0.782

NSb

Mean arterial pressure (mmHg)

47/54

84 ± 9

85 ± 12

0.7 ± 14

83 ± 8

86 ± 12

3 ± 14

0.387

0.020 c

Heart rate (bpm)

53/56

98 ± 23

106 ± 20

8 ± 29

103 ± 20

99 ± 19

−4 ± 28

0.073

0.058 d

Plasma triacylglycerol (mmol/L)

56/59

1.24 (0.85;1.89)a

1.08 (0.78;1.39)b

−0.13 (−0.55;0.22)

1.41 (0.91;2.10)

1.42 (0.94;1.76)

0.09 (−0.69;0.42)

0.014

0.017 e

Plasma total cholesterol (mmol/L)

56/59

4.06 ± 0.83

4.04 ± 0.83

−0.02 ± 0.87

4.07 ± 0.91

4.00 ± 0.73

−0.07 ± 0.88

0.725

0.879f

Plasma LDL-cholesterol (mmol/L)

56/59

2.33 ± 0.66

2.34 ± 0.66

0.02 ± 0.64

2.36 ± 0.78

2.44 ± 0.66

0.07 ± 0.68

0.469

0.369g

Plasma HDL-cholesterol (mmol/L)

56/59

1.10 ± 0.26a

1.00 ± 0.25b

−0.11 ± 0.29

1.06 ± 0.25a

0.96 ± 0.19b

−0.09 ± 0.24

0.652

NSb

Plasma insulin (pmol/L)

56/56

31 (15;65)

31 (14;56)

−1.1 ± 60.6

39 (22;62)

29.3 (16;55)

−5.5 ± 54.6

0.730

0.770e

Plasma glucose (mmol/L)

56/60

5.14 ± 0.71

5.09 ± 0.64

−0.05 ± 0.93

5.24 ± 0.56

5.28 ± 0.69

0.04 ± 0.79

0.159

NSb

HOMA

55/56

1.15 (0.51;2.46)

1.17 (0.44;1.96)

−0.10 ± 2.45

1.49 (0.79;2.48)

1.10 (0.65; 2.03)

−0.17 ± 2.49

0.611

0.570h

  1. Values are mean ± SD or median (25th–75th quartiles)
  2. p values in bold are p < 0.05
  3. p, ANCOVA of group effects adjusted for baseline values
  4. p adj, ANCOVA of group effects adjusted for baseline values and potential confounders specified below
  5. Values in a row with different letters indicate significantly different within group changes (p < 0.05) according to paired t test
  6. FO fish oil and SO sun flower oil
  7. aAdjusted for baseline values and BP apparatus
  8. bEqual to unadjusted, as no covariates had a significant effect
  9. c p value is for group × gender (also adjusted for baseline values). Boys have lower MAP (p = 0.028), but no significant difference among girls (p = 0.243) in FO versus SO
  10. dAdjusted for baseline values and BMI at 18 months
  11. eAdjusted for baseline values and energy content of last meal
  12. fAdjusted for baseline values, gender, and energy content of last meal
  13. gAdjusted for baseline values, gender, energy content of last meal, and fasting time
  14. hAdjusted for baseline values, BMI at 18 months, and energy content of last meal