Table 1 Pathways with the highest number of genes carrying rare variants with a high-to-moderate predicted biological effect ranked by Panther
Pathway | Genes | |
|---|---|---|
1 | Wnt signaling | 32 |
2 | Inflammation mediated by chemokine and cytokine signaling | 26 |
3 | Integrin signaling pathway | 21 |
4 | Cadherin signaling pathway | 19 |
5 | Gonadotropin releasing hormone receptor | 17 |
6 | Nicotinic acetylcholine receptor signaling | 14 |
7 | PDGF signaling | 13 |
8 | Angiogenesis | 13 |
9 | Cytoskeletal regulation by Rho GTPase | 12 |
10 | Huntington disease | 12 |