Fig. 1

Schematic representation of the convergence of pathways of the proposed therapeutic targets. The modulations of the activity of both AMPK and sirtuins (as, for example, the discussed Sirt1) lead to a potent activation of PGC-1α which, in turn, binds to an increase in the transcriptional activity of key target transcription factors. One example is PPARγ, a key transcription factor for metabolism. By acting on these targets, it is possible to elucidate molecular pathways and unveil therapeutic targets for exploration in the near future