High-fat and obesogenic diets: current and future strategies to fight obesity and diabetes

Genes & Nutrition

Table 1 Comparison between various types of obesogenic diets, and indication of various studies that have used them, as well as the animal model utilized and main results obtained

Diet	Model	Effect	References
HFD	Rat	Hepatic insulin resistance	Samuel et al. (2004)
		Hepatic fat deposition
MCD	Mouse	Proinflammatory gene expression	Lee et al. (2007)
		Hepatic steatosis
HFD	Mouse	Hyperleptinemia	Wang et al. (2002)
		Decreased NPY gene expression
MCD	Rat	High cholesterol in serum	Hussein et al. (2007)
		Hepatic steatosis
HFD	Rat	Insulin resistance	Buettner et al. (2006)
		Pronounced obesity
HFrD	Various	Insulin resistance	Basciano et al. (2005)
		Hypertriglyceridemia
MCD	Mouse	Hepatic steatosis	Sahai et al. (2004)
		Increase in inflammatory factors expression
MCD	Mouse	No obesity	Rinella and Green (2004)
		No insulin resistance
MCD		Hepatocellular damage	Pickens et al. (2010)
+ HFrD		Hepatic steatosis
CD	Rat	Hepatic steatosis	Fujita et al. (2010)
		Hepatic fibrosis
CD	Rat	Hepatic mitochondrial dysfunction	Teodoro et al. (2008)
		Increased triglyceride hepatic deposition
CDAA		Heightened oxidative stress	Takeuchi-Yorimoto et al. (2013)
		Steatohepatitis

ISSN: 1865-3499