Fig. 4
From: Genetic associations with micronutrient levels identified in immune and gastrointestinal networks
Methodological approach to the correlation of genotype and metabolite profile via network analysis. Metabolite data were first summarized by a single principal component and compared to each SNP (gray boxes) in the genetic dataset using GEE. Nominal p values from the GEE analysis (SNPs in red boxes) were used as input to the VEGAS algorithm to determine gene-level p values from SNP-level data (red lines indicate a gene with multiple SNPs, black line with single SNPs). Significant genes were then mapped to the global interaction network and considered as “hits” in hypergeometric tests of each topological module in the network