Genetic predisposition scores for dyslipidaemia influence plasma lipid concentrations at baseline, but not the changes after controlled intake of n-3 polyunsaturated fatty acids

Table 1 Characteristics of study participants at baseline by randomised treatment

	Placebo	0.45 g/day	0.9 g/day	1.8 g/day	P*
	n = 70	n = 80	n = 80	n = 80	P*
Gender
Male, n (%)	31, 44	30, 37.5	30, 37.5	29, 36
Female, n (%)	39, 56	50, 62.5	50, 62.5	51, 64
Ethnicity
White, n (%)	57, 81.4	64, 80.0	64, 80.0	69, 86.25
Far Eastern, n (%)	6, 8.6	4, 5.0	5, 6.25	1, 1.25
S. Asian, n (%)	3, 4.3	6, 7.5	8, 10.0	1, 1.25
Black, n (%)	2, 2.85	3, 3.75	0, 0.0	4, 5.0
Other, n (%)	2, 2.85	3, 3.75	3, 3.75	5, 6.25
Age (years)	55.4 ± 6.9	55.1 ± 6.8	55.2 ± 6.6	55.1 ± 6.7	0.99
BMI (kg/m²)	26.1 ± 3.7	25.1 ± 3.9	26.2 ± 4.0	25.2 ± 3.5	0.17
Waist circumference (cm)	89.5 ± 11.7	87.3 ± 11.8	89.4 ± 11.9	88.0 ± 11.0	0.60
Plasma lipids (mmol/L)
TC	5.4 ± 1.0	5.4 ± 1.1	5.4 ± 0.9	5.4 ± 1.0	0.94
HDL-C	1.6 ± 0.5	1.6 ± 0.4	1.7 ± 0.5	1.7 ± 0.5	0.26
LDL-C	3.3 ± 0.8	3.2 ± 0.8	3.2 ± 0.8	3.2 ± 0.7	0.79
TG^a	1.2 ± 0.5	1.1 ± 0.5	1.1 ± 0.4	1.1 ± 0.5	0.96

Data are presented for subjects randomised to treatment groups for whom DNA was available (n = 310). Measurements taken at baseline after 4-week run-in on normal diet with olive oil placebo supplement are shown for each randomised treatment group: placebo and EPA and DHA (1.51:1) at the daily doses shown. Values are n (%) for gender and ethnic groups, or mean ± SD for all other variables except TG
BMI body mass index, HDL-C high-density-lipoprotein cholesterol, LDL-C low-density-lipoprotein cholesterol, TC total cholesterol, TG triglyceride
* Significance of differences between treatment groups assessed by one-way ANOVA. P value for difference in age, adjusted for BMI, gender and ethnicity; for differences in BMI and waist circumference, adjusted for age, gender and ethnicity; for differences in plasma lipid concentrations, adjusted for BMI, age, gender and ethnicity
^aTG data not normally distributed and presented as the geometric mean ± SE

ISSN: 1865-3499