Genetic predisposition scores for dyslipidaemia influence plasma lipid concentrations at baseline, but not the changes after controlled intake of n-3 polyunsaturated fatty acids

Table 2 Effect of GPS on plasma TC, HDL-C, LDL-C and TG concentrations at baseline

	Effect	SE	P*	r ²	n
TC (mmol/L)	0.114	0.032	0.07	0.056	252
HDL-C (mmol/L)	−0.011	0.015	0.08	0.306	252
LDL-C (mmol/L)	0.065	0.028	0.30	0.033	252
lnTG (mmol/L)^a	0.210	0.013	<0.0001	0.205	252

Data show associations of GPS with each trait, presented as per allele effect size, and SE derived from linear regression models of GPS against trait at baseline. The proportion of explained variance is indicated by r ² and n is the number of participants in each subgroup. A negative effect represents an association with reduction in trait at baseline
HDL-C high-density-lipoprotein cholesterol, LDL-C low-density-lipoprotein cholesterol, TC total cholesterol, TG triglyceride
* Significance of per allele effect on change in trait derived from linear regression models, nominal at P < 0.05. P values adjusted for BMI, age, gender and ethnicity
^aTG data were logged for the analysis and were presented as log(n)-transformed data

ISSN: 1865-3499