Table 2 The association between SNPs in CYP2R1 and GC gene, and 25(OH)D concentrations at baseline (all) and at the end of the study (control/fortification)

CYP2R1

Group

 rs10741657

AA

GA

GG

P_adj

AA

GA

GG

P_adj

All

76.6 (73.0–80.5)

73.9 (71.8–76.1)

67.2 (65.0–69.5)

<0.0001

Control

40.6 (36.4–45.3)

43.1 (40.3–46.1)

39.8 (36.8–43.1)

0.1240

(n = 125)

(n = 365)

(n = 268)

(n = 66)

(n = 175)

(n = 128)

Fortification

69.1 (64.3–74.3)

69.7 (67.0–72.5)

63.1 (60.4–66.0)

0.0130

(n = 51)

(n = 171)

(n = 133)

 rs10766197

GG

AG

AA

GG

AG

AA

All

74.3 (71.6–77.1)

72.9 (70.8–75.1)

66.9 (64.2–69.8)

<0.0001

Control

41.5 (38.2–45.1)

42.6 (39.9–45.6)

38.7 (34.8–43.0)

0.1996

(n = 221)

(n = 359)

(n = 177)

(n = 116)

(n = 181)

(n = 72)

Fortification

68.3 (64.6–72.1)

68.0 (65.3–70.8)

64.3 (61.0–67.7)

0.0599

(n = 91)

(n = 164)

(n = 99)

GC

 rs4588

CC

CA

AA

CC

CA

AA

All

75.1 (73.1–77.2)

69.9 (67.7–72.1)

61.2 (56.9–62.9)

<0.0001

Control

41.2 (38.7–44.0)

41.4 (38.5–44.5)

44.6 (37.1–53.5)

0.4163

(n = 400)

(n = 303)

(n = 55)

(n = 193)

(n = 152)

(n = 24)

Fortification

70.9 (68.3–73.5)

64.6 (61.8–67.4)

55.0 (49.9–60.6)

<0.0001

(n = 191)

(n = 137)

(n = 27)

rs842999

GG

GX (GA or GC)

XX (CC, CA, AA)

GG

GX (GA or GC)

XX (CC, CA, AA)

All

75.4 (72.7–78.3)

72.7 (70.7–74.8)

65.0 (62.2–68.0)

<0.0001

Control

40.5 (37.1–44.2)

43.5 (40.8–46.5)

38.0 (34.4–42.0)

0.4099

(n = 217)

(n = 383)

(n = 152)

(n = 104)

(n = 185)

(n = 79)

Fortification

72.4 (68.9–76.1)

66.8 (64.3–69.4)

60.2 (56.5–64.0)

<0.0001

(n = 105)

(n = 179)

(n = 67)