Baseline | End of study | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Geometric mean 25(OH)D nmol/L (95 % CI) | Geometric mean 25(OH)D nmol/L (95 % CI) | |||||||||
CYP2R1 | Group | |||||||||
rs10741657 | AA | GA | GG | Padj | AA | GA | GG | Padj | ||
All | 76.6 (73.0–80.5) | 73.9 (71.8–76.1) | 67.2 (65.0–69.5) | <0.0001 | Control | 40.6 (36.4–45.3) | 43.1 (40.3–46.1) | 39.8 (36.8–43.1) | 0.1240 | |
(n = 125) | (n = 365) | (n = 268) | (n = 66) | (n = 175) | (n = 128) | |||||
Fortification | 69.1 (64.3–74.3) | 69.7 (67.0–72.5) | 63.1 (60.4–66.0) | 0.0130 | ||||||
(n = 51) | (n = 171) | (n = 133) | ||||||||
rs10766197 | GG | AG | AA | GG | AG | AA | ||||
All | 74.3 (71.6–77.1) | 72.9 (70.8–75.1) | 66.9 (64.2–69.8) | <0.0001 | Control | 41.5 (38.2–45.1) | 42.6 (39.9–45.6) | 38.7 (34.8–43.0) | 0.1996 | |
(n = 221) | (n = 359) | (n = 177) | (n = 116) | (n = 181) | (n = 72) | |||||
Fortification | 68.3 (64.6–72.1) | 68.0 (65.3–70.8) | 64.3 (61.0–67.7) | 0.0599 | ||||||
(n = 91) | (n = 164) | (n = 99) | ||||||||
GC | ||||||||||
rs4588 | CC | CA | AA | CC | CA | AA | ||||
All | 75.1 (73.1–77.2) | 69.9 (67.7–72.1) | 61.2 (56.9–62.9) | <0.0001 | Control | 41.2 (38.7–44.0) | 41.4 (38.5–44.5) | 44.6 (37.1–53.5) | 0.4163 | |
(n = 400) | (n = 303) | (n = 55) | (n = 193) | (n = 152) | (n = 24) | |||||
Fortification | 70.9 (68.3–73.5) | 64.6 (61.8–67.4) | 55.0 (49.9–60.6) | <0.0001 | ||||||
(n = 191) | (n = 137) | (n = 27) | ||||||||
rs842999 | GG | GX (GA or GC) | XX (CC, CA, AA) | GG | GX (GA or GC) | XX (CC, CA, AA) | ||||
All | 75.4 (72.7–78.3) | 72.7 (70.7–74.8) | 65.0 (62.2–68.0) | <0.0001 | Control | 40.5 (37.1–44.2) | 43.5 (40.8–46.5) | 38.0 (34.4–42.0) | 0.4099 | |
(n = 217) | (n = 383) | (n = 152) | (n = 104) | (n = 185) | (n = 79) | |||||
Fortification | 72.4 (68.9–76.1) | 66.8 (64.3–69.4) | 60.2 (56.5–64.0) | <0.0001 | ||||||
(n = 105) | (n = 179) | (n = 67) |