Heritability and genetic etiology of habitual physical activity: a twin study with objective measures

Genes & Nutrition

Table 5 Associations between parameters of habitual physical activity and SNPs in PPARD and PPARGC1A obtained by meta-analysis

Phenotype	Gene	SNP	Genotype/Haplotype	Beta	P value	Heterogeneity
HPA	PPARD	rs2267668	AG	−384.3	0.005	0.41
			GG	−684.6	0.057	0.15
	PPARD	rs2076168	AC	−247.5	0.053	0.68
			CC	−801.1	0.006	0.43
	PPARD	Haplotype	AA and GC	−348.4	0.017	0.96
High	PPARGC1A	rs8192678	GA	−0.139	0.27	0.49
High			AA	0.671	0.001

HPA, habitual physical activity in Mcnts/day; %High, the time spent on high-intensity physical activity in min/d; for rs2267668 and rs2076168 in PPARD, AA carriers are the reference group; for the haplotype analysis, AA AA and AA AC haplotype carriers are the reference group; for rs8192678 in PPARGC1A, GG carriers are the reference group. High was natural log transformed. Heterogeneity refers to the P value of Q statistic

ISSN: 1865-3499