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Table 4 Genes related to GAG metabolism and extracellular matrix dynamics differentially expressed between Mobilee™ and placebo groups post-intervention (p < 0.05), but not pre-intervention

From: Blood cells transcriptomics as source of potential biomarkers of articular health improvement: effects of oral intake of a rooster combs extract rich in hyaluronic acid

Gene

Name

Systematic name

Function

Fold change Mobilee™ vs. placebo

p value

GUSB

Glucuronidase-beta

NM_000181

Hydrolase that degradates GAG

−1.22

0.027

HS6ST1

Heparan sulfate 6-O-sulfotransferase 1

NM_004807

Enzyme responsible for 6-O-sulfation of heparan sulfate

−1.22

0.009

MMP23B

Matrix metallopeptidase 23B

NM_006983

Protease involved in the breakdown of the extracellular matrix

−1.30

0.028

XYLT2

Xylosyltransferase II

NM_022167

Enzyme that initiates the biosynthesis of GAGs including chondroitin sulfate, heparan sulfate, heparin, and dermantan sulfate in proteoglycans

−1.32

0.004