Fig. 1

Examples of knowledge “triples” (or “propositions”). A triple consists of a subject, linking phrase (or “predicate”), and object. In this case, MTHFR is the subject of two triples, one with rs1801131 as an object and one with rs1801133 as an object. rs1801133 is also the subject of three triples linked with the phrase “has association” to the objects “increased thermolability of enzyme,” “enzyme activity reduction,” and “decreased substrate affinity.” The two linking phrases, “has variant” and “has association,” were used throughout the CMAP models. Inside of the web-accessible maps, the icon is a link to the literature reference(s) for the citation supporting the knowledge proposition that ends with the object upon which the icon sits