Concept mapping One-Carbon Metabolism to model future ontologies for nutrient–gene–phenotype interactions

Genes & Nutrition

Table 1 Linking phrase comparison

OCM CMAP Linking phrases	Relation ontology	Gene ontology	SOPHARM	New relations
Can be exacerbated by				✓
Can be mediated by				✓
Catalyzes				✓
Causes decrease in				✓
Causes increase in				✓
Characterized by				✓
Compared to group				✓
Expressed in	✓
Has association			✓
Has cofactor				✓
Has frequency				✓
Has function	✓
Has gene product	✓
In group				✓
Results in	✓
Located in	✓
Has parts	✓	✓	✓
Has variant	✓		✓
May utilize gene products from				✓
Utilizes gene products from				✓

This table depicts all linking phrases used in our CMAPs and compares them to those found in the relation ontology, the gene ontology, and SOPHARM. Those with checks are present in each ontology

ISSN: 1865-3499