Table 3 Characterization of literature mined genes absent in KEGG, WikiPathways, and GO
Function | Gene ID | OCM function | Pub Med link | References |
|---|---|---|---|---|
Aminoacyl-tRNA synthetase | MARS | Methionyl-tRNA synthetase (methionine + tRNA) | Wernimont et al. (2011) | |
Antigen synthesis | FUT2 | Influences B12 levels | Hazra et al. (2008) | |
B12 transport | CUBN | Intrinsic factor-cobalamin receptor | ||
TCblR | Transcobalamin receptor | Pangilinan et al. (2010) | ||
LMBRD1 | Lysosomal B12 transporter | Rutsch et al. (2011, p. 1) | ||
AMN | Essential for correct CUBN expression | Namour et al. (2011) | ||
TCN1 | B12 transport protein | Wernimont et al. (2011) | ||
ABC transporter | MRP1 | B12 export out of cells | Beedholm-Ebsen et al. (2010) | |
Sarcosine metabolism | DMGDH | Choline metabolism | Wernimont et al. (2011) | |
SARDH | Choline metabolism | |||
DNA synthesis and repair | MGMT | DNA methyltransferase | ||
MLH1 | DNA repair—depends on one-carbon supplies | Lim et al. (2007) | ||
MSH2 | DNA repair—depends on one-carbon supplies | Lim et al. (2007) | ||
Ferritin subunit | FTH1 | Regulates folate metabolism | ||
Folate transport and metabolism | GGH | Determines intercellular folate availability | ||
SLC19A1/PCFT | Folate transporter | Blanton et al. (2011) | ||
SLC19A2 | Thiamine (B1) transporter | Wernimont et al. (2011) | ||
SLC19A3 | Thiamine (B1) transporter | Wernimont et al. (2011) | ||
SLC25A32 | Mitochondrial folate carrier | Wernimont et al. (2011) | ||
SLC46A1 | Folate transporter | Kelemen et al. (2008) | ||
FOLR1 | Folate receptor | Blanton et al. (2011) | ||
FOLR2 | Folate receptor | Blanton et al. (2011) | ||
FOLR3 | Folate receptor | O’Byrne et al. (2010) | ||
Glycine metabolism | GCSH | Glycine cleavage | Wernimont et al. (2011) | |
GLDC | Glycine cleavage | Wernimont et al. (2011) | ||
Homocysteine metabolism | CBS | Converts homocysteine to cystathionine | Li et al. (2013) | |
CTH | Cystathionine gamma-lyase | Wernimont et al. (2011) | ||
Methylation of aspartic acid tRNAs | DNMT2 aka TRDM1 | DNA methyltransferase | Matakidou et al. (2007) | |
Methyl-CpG complex regulation | MBD2 | Binds to methylated DNA, demethylase | Lim et al. (2007) | |
Nitric oxide production | NOS3 | Inhibits MTR | Blanton et al. (2011) | |
Betaine metabolism | BHMT2 | Betaine–homocysteine methyltransferase | ||
Thymidylate metabolism | DPYD | Degradation of thymine | ||
Pre-mRNA splicing | CELF1 | Wernimont et al. (2011) | ||
Heat-shock protein | HSPA8 | Wernimont et al. (2011) | ||
Ubiquitination | UBE2N | Wernimont et al. (2011) | ||
UBE2I | Wernimont et al. (2011) |