Table 2 Genes associated with the top 5 canonical pathways. Lists of mRNAs differentially expressed between the control and the DHA groups was uploaded in the IPA tool (Ingenuity® Systems, www.ingenuity.com) and analyzed based on the IPA library of canonical pathways. The list of differentially expressed genes associated with each pathway is reported below
Gene symbol | Gene name | Entrez gene | Fold change | Type(s) |
|---|---|---|---|---|
Antigen-presenting pathway | ||||
B2 M | Beta-2-microglobulin | 12,010 | −1.301 | Transmembrane receptor |
CD74 | CD74 molecule. major histocompatibility complex. class II | 16,149 | −1.671 | Transmembrane receptor |
HLA-B | – | 15,018 | −1.291 | Transmembrane receptor |
HLA-C | Major histocompatibility complex. class I. C | 14,972 | −1.240 | Other |
HLA-DQA1 | Major histocompatibility complex. class II. DQ alpha 1 | 14,960 | −1.499 | Transmembrane receptor |
HLA-DRB1 | Major histocompatibility complex. class II. DR beta 1 | 14,969 | −1.690 | Transmembrane receptor |
PSMB9 | Proteasome (prosome. macropain) subunit. beta type. 9 | 16,912 | −1.294 | Peptidase |
Ox40 Signaling pathway | ||||
B2 M | Beta-2-microglobulin | 12,010 | −1.301 | Transmembrane receptor |
BCL2L1 | BCL2-like 1 | 12,048 | 1.493 | Other |
H2-Q8 | Histocompatibility 2. Q region locus 8 | 15,019 | −1.431 | Other |
HLA-B | – | 15,018 | −1.291 | Transmembrane receptor |
HLA-C | Major histocompatibility complex. class I. C | 14,972 | −1.240 | Other |
HLA-DQA1 | Major histocompatibility complex. class II. DQ alpha 1 | 14,960 | −1.499 | Transmembrane receptor |
HLA-DQB1 | Major histocompatibility complex. class II. DQ beta 1 | 14,961 | −1.675 | Other |
HLA-DRB1 | Major histocompatibility complex. class II. DR beta 1 | 14,969 | −1.690 | Transmembrane receptor |
JUN | Jun proto-oncogene | 16,476 | −1.525 | Transcription regulator |
Cytotoxic T lymphocyte-mediated apoptosis of target cells | ||||
B2M | Beta-2-microglobulin | 12,010 | −1.301 | Transmembrane receptor |
DFFA | DNA fragmentation factor. 45 kDa. alpha polypeptide | 13,347 | 1.461 | Enzyme |
H2-Q8 | Histocompatibility 2. Q region locus 8 | 15,019 | −1.431 | Other |
HLA-B | – | 15,018 | −1.291 | Transmembrane receptor |
HLA-C | Major histocompatibility complex. class I. C | 14,972 | −1.240 | Other |
HLA-DQA1 | Major histocompatibility complex. class II. DQ alpha 1 | 14,960 | −1.499 | Transmembrane receptor |
HLA-DQB1 | Major histocompatibility complex. class II. DQ beta 1 | 14,961 | −1.675 | Other |
HLA-DRB1 | Major histocompatibility complex. class II. DR beta 1 | 14,969 | −1.690 | Transmembrane receptor |
Allograft rejection signaling | ||||
B2 M | Beta-2-microglobulin | 12,010 | −1.301 | Transmembrane receptor |
H2-Q8 | Histocompatibility 2. Q region locus 8 | 15,019 | −1.431 | other |
HLA-B | – | 15,018 | −1.291 | Transmembrane receptor |
HLA-C | Major histocompatibility complex. class I. C | 14,972 | −1.240 | Other |
HLA-DQA1 | Major histocompatibility complex. class II. DQ alpha 1 | 14,960 | −1.499 | Transmembrane receptor |
HLA-DQB1 | Major histocompatibility complex. class II. DQ beta 1 | 14,961 | −1.675 | Other |
HLA-DRB1 | Major histocompatibility complex. class II. DR beta 1 | 14,969 | −1.690 | Transmembrane receptor |
Cross talk between dendritic cells and natural killer cells | ||||
ACTA1 | Actin. alpha 1. skeletal muscle | 11,459 | −1.314 | Other |
ACTG1 | Actin. gamma 1 | 11,465 | −1.315 | Other |
ACTG2 | Actin. gamma 2. smooth muscle. enteric | 11,468 | −1.394 | Other |
CCR7 | Chemokine (C–C motif) receptor 7 | 12,775 | −1.425 | G-protein-coupled receptor |
HLA-B | – | 15,018 | −1.291 | Transmembrane receptor |
HLA-C | Major histocompatibility complex. class I. C | 14,972 | −1.240 | Other |
HLA-DRB1 | Major histocompatibility complex. class II. DR beta 1 | 14,969 | −1.690 | Transmembrane receptor |
IL2RG | Interleukin 2 receptor. gamma | 16,186 | −1.253 | Transmembrane receptor |
TLN1 | Talin 1 | 21,894 | −1.324 | Other |