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Table 3 Most significant upstream regulators associated with the dataset

From: The omega-3 fatty acid docosahexaenoic acid favorably modulates the inflammatory pathways and macrophage polarization within aorta of LDLR−/− mice

Upstream regulator

Activation z-score

p value of overlap

(a) List of the most significant activated upstream regulators

PPARG

2.367

1.50E−13

PPARA

2.384

6.45E−10

PPARD

3.160

1.56E−08

estrogen receptor

2.688

2.50E−07

PPARα-RXRα

2.000

4.42E−04

RXRA

2.068

7.05E−03

ESRRA

2.414

8.68E−02

(b) List of the most significant inhibited upstream regulators

IFNG

−2.797

2.81E−14

NFkB (complex)

−2.360

6.32E−09

PRL

−2.153

1.07E−08

IL6

−2.226

7.88E−07

IL27

−2.613

1.26E−06

Pdgf (complex)

−2.574

4.99E−05

PDGF BB

−2.009

1.40E−04

TCR

−2.416

1.75E−04

Interferon alpha

−2.771

4.23E−04

IFN alpha/beta

−2.156

7.53E−04

CCL13

−2.425

2.30E−03

EBI3

−2.177

3.55E−03

EDN1

–2.672

3.74E−03

  1. The upstream regulator analysis is based on prior knowledge of expected effects between transcriptional regulators and their target genes stored in the Ingenuity® Knowledge Base. For each upstream regulator, the p value of overlap calls likely upstream regulators based on significant overlap between dataset genes and known targets regulated by a transcriptional regulator. The activation z-score is used to infer likely activation states of upstream regulators based on comparison with a model that assigns random regulation directions