Table 2 Changes in total, LDL and HDL-cholesterol and final serum concentrations of β-Cx after intervention according to NPC1L1 L272L and ABCG8 A632 V polymorphisms
Total cholesterol (mmol/l) | P* | c-LDL (mmol/l) | P* | c-HDL (mmol/l) | P* | β-Cx (µmol/l) | P* | |
|---|---|---|---|---|---|---|---|---|
Beverage containing plant sterols | ||||||||
NPC1L1 L272L | ||||||||
CC (n = 9) | 0.38 (0.29) | 0.041 | 0.33 (0.29) | 0.077 | −0.04 (0.06) | 0.800 | 0.230 (0.049) | 0.349 |
CG/GG (n = 10) | −0.29 (0.10) | −0.18 (0.12) | −0.02 (0.05) | 0.289 (0.042) | ||||
CC excluding outlier (n = 8) | 0.123 (0.168) | 0.952 | 0.100 (0.121) | 0.119 | −0.065 (0.056) | 0.543 | – | – |
ABCG8 A632 V | ||||||||
CC (n = 14) | −0.10 (0.12) | 0.157 | −0.04 (0.09) | 0.185 | −0.04 (0.04) | 0.694 | 0.237 (0.034) | 0.218 |
CT/TT (n = 5) | 0.42 (0.53) | 0.39 (0.50) | −0.001 (0.07) | 0.324 (0.060) | ||||
CT/TT excluding outlier (n = 4) | −0.070 (0.231) | 0.910 | 0.065 (0.264) | 0.910 | −0.052 (0.074) | 0.880 | – | – |
Beverage containing plant sterols plus β-Cx | ||||||||
NPC1L1 L272L | ||||||||
CC (n = 9) | −0.24 (0.19) | 0.962 | −0.27 (0.12) | 0.904 | −0.06 (0.06) | 0.325 | 0.968 (0.105) | 0.461 |
CG/GG (n = 10) | −0.25 (0.07) | −0.25 (0.07) | 0.01 (0.04) | 1.062 (0.065) | ||||
CC excluding outlier (n = 8) | −0.369 (0.158) | 0.485 | −0.343 (0.108) | 0.488 | −0.070 (0.065) | 0.283 | – | – |
ABCG8 A632 V | ||||||||
CC (n = 14) | −0.34 (0.09) | 0.042 | −0.31 (0.07) | 0.116 | −0.05 (0.04) | 0.129 | 0.980 (0.074) | 0.352 |
CT/TT (n = 5) | 0.08 (0.20) | 0.07 (0.13) | 0.06 (0.05) | 1.109 (0.047) | ||||
CT/TT excluding outlier (n = 4) | −0.097 (0.115) | 0.207 | −0.168 (0.113) | 0.363 | 0.071 (0.064) | 0.144 | – | – |