Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters

Torres-Sánchez, Luisa; López-Carrillo, Lizbeth; Blanco-Muñoz, Julia; Chen, Jia

doi:10.1007/s12263-014-0429-z

Table 5 Association between maternal intake of folate and vitamin B₁₂ and newborn’s anthropometric parameters according MTHFR 677 C>T genotypes

From: Maternal dietary intake of folate, vitamin B₁₂ and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters

Newborn’s anthropometric Parameters
MTHFR 677 C > T	Dietary intake	Weight^a (kg)		Length^a (cm)		BMI^a		Z-Score at birth^b
		Weight^a (kg)		Length^a (cm)		BMI^a		Weight-for-age		Length-for-age		BMI-for-age		Weight-for-length
		β	95 % CI	β	95 % CI	β	95 % CI	β	95 % CI	β	95 % CI	β	95 % CI	β	95 % CI
All^c	Folate (<400 μg/d)
	First trimester (n = 144)	0.07	−0.05; 0.20	0.15	−0.53; 0.84	0.26	−0.23; 0.76	0.17	−0.11; 0.44	0.07	−0.29; 0.43	0.22	−0.19; 0.62	0.17	−0.30; 0.64
	Third trimester (n = 147)	−0.09	−0.22; 0.03	−0.02	−0.68; 0.64	−0.27	−0.75; 0.21	−0.18	−0.44; 0.08	−0.05	−0.40; 0.30	−0.22	−0.62; 0.17	−0.17	−0.63; 0.28
	Vitamin B₁₂ (<2.0 μg/d)
	First trimester (n = 43)	−0.09	−0.24; 0.07	−0.88	−1.71; −0.04*	0.12	−0.49; 0.74	−0.24	−0.57; 0.10	−0.45	−0.89; −0.02*	−0.007	−0.51; 0.49	−0.06	−0.65; 0.52
	Third trimester (n = 44)	−1.0	−0.27; 0.07	−0.63	−0.15; 0.28	−0.01	−0.68; 0.65	−0.27	−0.63; 0.08	−0.38	−0.85; 0.08	−0.12	−0.65; 0.41	−0.11	−0.73; 0.51
TT	Folate (<400 μg/d)
	First trimester (n = 55)	0.11	−0.10; 0.32	−0.04	−1.30; 1.23	0.44	−0.38; 1.27	0.29	−0.16; 0.74	0.14	−0.45; 0.73	0.37	−0.30; 1.04	0.31	−0.48; 1.10
	Third trimester (n = 52)	−0.18	−0.39; 0.02	−0.40	−1.62; 0.82	−0.34	−1.14; 0.46	−0.30	−0.74; 0.14	−0.23	−0.81; 0.35	−0.22	−0.87; 0.43	−0.23	−0.99; 0.53
	Vitamin B₁₂ (<2.0 μg/d)
	First trimester (n = 13)	−0.13	−0.40; 0.14	−2.21	−4.21; −0.22**	0.56	−0.49; 1.61	−0.38	−0.95; 0.19	−1.12	−2.04; −0.21**	0.32	−0.53; 1.18	0.27	−0.75; 1.29
	Third trimester (n = 12)	−0.06	−0.37; 0.24	−2.47	−4.30; −0.64**	1.08	−0.09; 2.24	−0.10	−0.74; 0.53	−1.20	−2.30; −0.11^**	0.83	−0.55; 2.21	0.76	−0.27; 1.78
CC+CT	Folate (<400 μg/d)
	First trimester (n = 89)	0.08	−0.08; 0.24	−0.19	−0.91; 0.53	0.33	−0.27; 0.93	0.17	−0.16; 0.51	−0.003	−0.43; 0.43	0.28	−0.21; 0.78	0.24	−0.35; 0.85
	Third trimester (n = 95)	−0.02	−0.17; 0.13	0.02	−0.71; 0.75	−0.14	−0.70; 0.45	−0.07	−0.39; 0.25	0.02	−0.39; 0.43	−0.14	−0.61; 0.34	−0.05	−0.62; 0.53
	Vitamin B₁₂(<2.0 μg/d)b12
	First trimester (n = 32)	−0.07	−0.27; 0.12	−0.37	−1.34; 0.60	0.04	−0.69; 0.77	−0.13	−0.54; 0.27	−0.22	−0.74; 0.30	−0.03	−0.64; 0.57	−0.09	−0.82; 0.64
	Third trimester (n = 32)	−0.14	−0.34; 0.06	−0.14	−1.18; 0.89	−0.49	−1.26; 0.27	−0.35	−0.77; 0.07	−0.14	−0.69; 0.40	−0.45	−1.07; 0.18	−0.34	−1.09; 0.41

^aAdjusted by: maternal age, schooling, parity, BMI during first trimester, energy, calcium, iron and zinc dietary intake, gestational age (weeks), sex of child and vitamin supplementation during pregnancy (yes/no)
^bAdjusted by: maternal age, schooling, parity, BMI during first trimester, energy, calcium, iron and zinc dietary intake and vitamin supplementation during pregnancy (yes/no)
^cAdjusted by MTHFR 677 C>T
* p < 0.05
** p for interaction < 0.05

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