From: Meat-derived carcinogens, genetic susceptibility and colorectal adenoma risk
Gene | rs | Genotype category | PhIP intake > 232.61a | DiMeIQx intake > 4.12a | Meat mutagenicity > 7,179.67a |
---|---|---|---|---|---|
Adjusted OR (95Â % CI)b | Adjusted OR (95Â % CI)b | Adjusted OR (95Â % CI)b | |||
CYP1A2 | 762551 | AC/CC | 1.50 (0.70–3.23) | 1.79 (0.84–3.83) | 1.59 (0.75–3.39) |
AA | 0.58 (0.27–1.25) | 1.08 (0.51–2.27) | 0.84 (0.39–1.79) | ||
CYP1B1 | 10012; 1056827 | CC + GG | 0.42 (0.18–0.96) c | 0.93 (0.42–2.07) | 0.51 (0.22–1.16) c |
CG/GG + GT/TT | 1.91 (0.85–4.26) c | 1.77 (0.80–3.89) | 2.68 (1.18–6.09) c | ||
NAT2 | 1041983 | TT | 1.11 (0.53–2.34) | 1.36 (0.65–2.85) | 1.27 (0.61–2.67) |
CC/CT | 0.77 (0.37–1.64) | 1.41 (0.66–2.98) | 1.04 (0.50–2.18) | ||
XPA | 1800975 | CT/TT | 0.92 (0.46–1.83) | 0.95 (0.47–1.90) | 1.18 (0.59–2.34) |
CC | 0.98 (0.45–2.15) | 2.02 (0.94–4.36) | 1.09 (0.50–2.39) | ||
XPD | 13181;1799793 | AA + GG | 0.42 (0.19–0.94) c | 0.77 (0.35–1.69) c | 0.75 (0.35–1.63) |
CC/CA + AA/GA | 1.84 (0.88–3.84) c | 2.28 (1.01–4.74) c | 1.68 (0.82–3.48) | ||
XRCC1 | 25487 | GG | 0.80 (0.36–1.78) | 1.83 (0.83–4.05) | 1.48 (0.67–3.26) |
AA/AG | 1.07 (0.51–2.24) | 1.06 (0.52–2.19) | 0.97 (0.47–2.01) | ||
ADPRT | 1136410 | TT | 0.92 (0.48–1.77) | 1.75 (0.91–3.36) | 1.02 (0.53–1.96) |
CC/CT | 0.97 (0.39–2.40) | 0.89 (0.36–2.22) | 1.45 (0.59–3.63) | ||
XPC | 2228001 | AA | 0.90 (0.37–2.22) | 1.20 (0.48–2.97) | 1.08 (0.43–2.70) |
CC/CA | 1.04 (0.53–2.02) | 1.58 (0.82–3.05) | 1.28 (0.67–2.48) | ||
XRCC3 | 861539 | CC | 1.50 (0.62–3.60) | 1.25 (0.53–2.96) | 2.31 (0.96–5.57) |
TT/TC | 0.77 (0.39–1.55) | 1.40 (0.71–2.76) | 0.85 (0.43–1.69) |