Gender-specific genetic associations of polymorphisms in ACE, AKR1C2, FTO and MMP2 with weight gain over a 10-year period

Table 3 Genotype and allele frequencies per polymorphism in the whole study population

Gene	Polymorphism	Genotypes	n	F (%)	Allele	F (%)	HWE^a
ACE	rs4340	Del/Del	141	28.4	Del	55.1	0.10
		Del/Ins	263	53.0	Ins	44.9
		Ins/Ins	91	18.3
FTO	rs9939609	A/A	78	15.7	A	38.0	0.14
		A/T	214	43.1	T	62.0
		T/T	195	39.3
AKR1C2	rs2854482	A/A	457	92.1	A	96.1	0.36
	F46Y	A/T	39	7.9	T	3.9
		T/T	0	0
AKR1C2	rs4143631	C/C	258	52.0	C	71.2	0.20
Promoter		C/T	191	38.5	T	28.8
		T/T	47	9.5
AKR1C2	rs12249281	A/A	129	26.0	A	48.9	0.07
Promoter		A/G	227	45.8	G	51.1
		G/G	140	28.2
TIMP4	rs3755724	C/C	219	44.2	C	66.4	0.84
		C/T	219	44.2	T	33.6
		T/T	57	11.5
MMP2	rs1132896	C/C	60	12.1	C	35.6	0.63
		C/G	231	46.6	G	64.4
		G/G	202	40.7

n number of subjects; F relative frequency (%)
^a p values obtained from the Chi square test of Hardy–Weinberg equilibrium (HWE)

ISSN: 1865-3499