Gender-specific genetic associations of polymorphisms in ACE, AKR1C2, FTO and MMP2 with weight gain over a 10-year period

Table 5 Results of logistic regression analysis with weight gain as dependent variable (stable weight is reference) and the genotypes as independent variable adjusted for baseline age and BMI

Gene	rs number	Genotype/model	Men				Women
Gene	rs number	Genotype/model	Stable weight (n)	Weight gainers (n)	Odds ratio (95 % CI)	p	Stable weight (n)	Weight gainers (n)	Odds ratio (95 % CI)	p
ACE	rs4340	I/I versus	14	23	1.91 (0.93–3.93)	0.077	29	25	0.94 (0.51–1.72)	0.831
		D/D–D/I^b	117	97			98	92
FTO	rs9939609	A/A–A/T versus	71	83	1.99 (1.16–3.39)	0.012*	73	65	0.95 (0.57–1.58)	0.845
		T/T^a	56	35			54	50
AKR1C2	rs2854482	A/A versus	120	110	1.17 (0.48–2.85)	0.722	118	109	1.03 (0.38–2.77)	0.960
		A/T^c	12	10			9	8
AKR1C2	rs4143631	T/T versus	9	11	1.47 (0.58–3.72)	0.412	13	14	1.15 (0.51–2.58)	0.736
		C/C–C/T^b	123	109			114	103
AKR1C2	rs12249281	A/A versus	27	35	1.57 (0.88–2.82)	0.128	35	32	0.97 (0.55–1.71)	0.909
		G/G–G/A^b	105	85			92	85
TIMP4	rs3755724	T/T–T/C versus	61	49	1.28 (0.77–2.14)	0.345	71	64	0.97 (0.58–1.61)	0.909
		C/C^a	71	70			56	53
MMP2	rs1132896	C/C–C/G versus	72	62	0.90 (0.55–1.50)	0.693	70	87	2.50 (1.44–4.35)	0.001*
		G/G^a	59	57			57	29

ISSN: 1865-3499