Fig. 2
Effect of the MTHFR 677C>T polymorphism on tHcy according to riboflavin or riboflavin combined with folate status. Effect of the variant MTHFR 677T allele compared to 677CC genotype on tHcy: according to EGRAC status (a) or EGRAC and plasma folate status (below, or in the upper tertile, ≥14.7 nmol/L) (b). LntHcy was the dependent variable in the multiple linear regression analyses represented in both panels. The models were adjusted for plasma cobalamin, folate and creatinine, EASTAC, smoking habit (smoker versus non-smoker), alcohol intake (g/week), age, sex, BMI, socioeconomic level and study centre. The interaction term (EGRAC × genotype) was included in the models and, when significant, indicated that riboflavin status altered the association between the genotype and tHcy. All of the models were significant (p < 0.001) with R 2 ranging from 0.308 to 0.631. *p < 0.05 compared to MTHFR 677CC